Dalteparin sodium


Dalteparin sodium

Dalteparin is a low molecular weight heparin. It is marketed as Fragmin® by Pfizer Inc. Like other low molecular weight heparins, dalteparin is used for prophylaxis or treatment of deep vein thrombosis and pulmonary embolism.

The CLOT study, published in 2003, showed that in patients with malignancy and acute venous thromboembolism, dalteparin was more effective than warfarin in reducing the risk of recurrent embolic events.[1] Dalteparin is not superior to unfractionated heparin in preventing blood clots.[2]

Tinzaparin sodium is the only low molecular weight heparin shown to be safe in critically ill people with renal failure at both treatment and prophylaxis dose levels.[3]. Heparins are cleared by the kidneys, but studies have shown that dalteparin does not accumulate even if kidney function is reduced.[4]

References

  1. ^ Lee AY, Levine MN, Baker RI, Bowden C, Kakkar AK, Prins M, Rickles FR, Julian JA, Haley S, Kovacs MJ, Gent M (2003). "Low-molecular-weight heparin versus a Coumadin for the prevention of recurrent venous thromboembolism in patients with cancer". N Engl J Med 349 (2): 146–53. doi:10.1056/NEJMoa025313. PMID 12853587. 
  2. ^ The PROTECT Investigators for the Canadian Critical Care Trials Group and the Australian and New Zealand Intensive Care Society Clinical Trials Group (2011). Dalteparin versus unfractionated heparin in critically ill patients. doi:10.1056/NEJMoa1014475. 
  3. ^ Nagge J, Crowther M, Hirsch J (2002). "Is Impaired Renal Function a Contraindication to the Use of Low-Molecular-Weight Heparin?". Arch Intern Med. 162 (22): 2605–2609. doi:10.1001/archinte.162.22.2605. PMID 12456233. 
  4. ^ Douketis J, Cook D, Meade M et al. (2008). "Prophylaxis against deep vein thrombosis in critically ill patients with severe renal insufficiency with the low-molecular-weight heparin dalteparin". Arch Intern Med 168 (16): 1805–1812. doi:10.1001/archinte.168.16.1805. PMID 18779469. 

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • dalteparin sodium — dal·tep·a·rin so·di·um (dal tepґə rin) an antithrombotic prepared from heparin sodium derived from porcine intestinal mucosa; it enhances the inhibition of factor Xa and thrombin by antithrombin. It is administered subcutaneously for the… …   Medical dictionary

  • Enoxaparin sodium — Clinical data AHFS/Drugs.com monograph …   Wikipedia

  • Ardeparin sodium — Systematic (IUPAC) name 6 [5 acetylamino 4,6 dihydroxy 2 (sulfooxymethyl)tetrahydropyran 3 yl]oxy 3 [5 (6 Clinical data AHFS/Drugs.com …   Wikipedia

  • Тромбоэмболия лёгочной артерии — Тромбоэмболия легочной артерии КТ картина тромбоэмболии гла …   Википедия

  • low-molecular-weight heparin — a type of heparin that is more readily absorbed and requires less frequent administration than standard heparin preparations used as parenteral anticoagulant therapy to prevent deep vein thrombosis following surgery or during kidney dialysis.… …   The new mediacal dictionary

  • Фрагмин — Действующее вещество ›› Далтепарин натрия* (Dalteparin sodium*) Латинское название Fragmin АТХ: ›› B01AB04 Далтепарин Фармакологическая группа: Антикоагулянты Нозологическая классификация (МКБ 10) ›› I20.0 Нестабильная стенокардия ›› I26 Легочная …   Словарь медицинских препаратов

  • Fragmin — Frag·min (fragґmin) trademark for a preparation of dalteparin sodium …   Medical dictionary

  • Heparin — Systematic (IUPAC) name see Hep …   Wikipedia

  • Arixtra — Strukturformel …   Deutsch Wikipedia

  • Faktor Xa-inhibitor — Strukturformel …   Deutsch Wikipedia