DNA polymerase mu


DNA polymerase mu
Polymerase (DNA directed), mu

PDB rendering based on 2dun.
Identifiers
Symbols POLM; FLJ35482; Pol Mu; Tdt-N
External IDs OMIM606344 MGI1860191 HomoloGene41170 GeneCards: POLM Gene
EC number 2.7.7.7
RNA expression pattern
PBB GE POLM 222238 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 27434 54125
Ensembl ENSG00000122678 ENSMUSG00000020474
UniProt Q9NP87 Q7TN90
RefSeq (mRNA) NM_013284 NM_017401.2
RefSeq (protein) NP_037416 NP_059097.2
Location (UCSC) Chr 7:
44.11 – 44.12 Mb
Chr 11:
5.73 – 5.74 Mb
PubMed search [1] [2]

DNA polymerase mu is a human protein encoded by the POLM gene.[1]

Function

Pol μ is a member of the X family of DNA polymerases. It participates in resynthesis of damaged or missing nucleotides during the non-homologous end joining (NHEJ) pathway of DNA repair.[2] Pol μ interacts with Ku and DNA ligase IV, which also participate in NHEJ.[3] It is structurally and functionally related to pol λ, and, like pol λ, pol μ has a BRCT domain that is thought to mediate interactions with other DNA repair proteins.[4] Unlike pol λ, however, pol μ has the unique ability to add a base to a blunt end that is templated by the overhang on the opposite end of the double-strand break.[5] Pol μ is also closely related to terminal deoxynucleotidyl transferase (TdT), a specialized DNA polymerase that adds random nucleotides to DNA ends during V(D)J recombination, the process by which B-cell and T-cell receptor diversity is generated in the vertebrate immune system. Like TdT, pol μ participates in V(D)J recombination, but only during heavy chain rearrangements.[6] This is distinct from pol λ, which is involved in light chain rearrangements.[7]

References

  1. ^ "Entrez Gene: POLM polymerase (DNA directed), mu". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27434. 
  2. ^ Daley JM, Laan RL, Suresh A, Wilson TE (August 2005). "DNA joint dependence of pol X family polymerase action in nonhomologous end joining". J. Biol. Chem. 280 (32): 29030–7. doi:10.1074/jbc.M505277200. PMID 15964833. 
  3. ^ Mahajan KN, Nick McElhinny SA, Mitchell BS, Ramsden DA (July 2002). "Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair". Mol. Cell. Biol. 22 (14): 5194–202. doi:10.1128/MCB.22.14.5194-5202.2002. PMC 139779. PMID 12077346. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139779. 
  4. ^ Nick McElhinny SA, Ramsden DA (August 2004). "Sibling rivalry: competition between Pol X family members in V(D)J recombination and general double strand break repair". Immunol. Rev. 200: 156–64. doi:10.1111/j.0105-2896.2004.00160.x. PMID 15242403. 
  5. ^ Nick McElhinny SA, Havener JM, Garcia-Diaz M, et al. (August 2005). "A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining". Mol. Cell 19 (3): 357–66. doi:10.1016/j.molcel.2005.06.012. PMID 16061182. 
  6. ^ Bertocci B, De Smet A, Berek C, Weill JC, Reynaud CA (August 2003). "Immunoglobulin kappa light chain gene rearrangement is impaired in mice deficient for DNA polymerase mu". Immunity 19 (2): 203–11. doi:10.1016/S1074-7613(03)00203-6. PMID 12932354. 
  7. ^ Bertocci B, De Smet A, Weill JC, Reynaud CA (July 2006). "Nonoverlapping functions of DNA polymerases mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo". Immunity 25 (1): 31–41. doi:10.1016/j.immuni.2006.04.013. PMID 16860755. 

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • DNA-Polymerase — Bänderdarstellung der DNA bindenden Domäne der humanen DNA Polymerase β …   Deutsch Wikipedia

  • DNA polymerase — (d[=e] [e^]n*[=a] p[o^]*l[i^]m [ e]r*[=a]s) n. (Biochemistry, Genetics) an enzyme that catalyzes the formation of DNA from deoxyribonucleoside triphosphates. Cells contain several types of DNA polymerase, some of which are required for… …   The Collaborative International Dictionary of English

  • DNA polymerase — DNA polymerase. См. ДHK полимераза. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • DNA polymerase ### — DNA polymerase ###. См. ДНК полимераза ###. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • DNA-Polymerase —  DNA Polymerase  ДНК полимераза   Фермент, катализирующий синтез полинуклеотидной цепи из отдельных нуклеотидов с использованием другой цепи в качестве матрицы и ДНК затравки со свободной 3’–ОН группой …   Толковый англо-русский словарь по нанотехнологии. - М.

  • DNA polymerase — 3D structure of the DNA binding helix turn helix motifs in human DNA polymerase beta A DNA polymerase is an enzyme that helps catalyze in the polymerization of deoxyribonucleotides into a DNA strand. DNA polymerases are best known for their… …   Wikipedia

  • DNA polymerase I — Functional domains in the Klenow Fragment (left) and DNA Polymerase I (right). DNA Polymerase I (or Pol I) is an enzyme that participates in the process of DNA replication in prokaryotes. It is composed of 928 amino acids, and is an example of a… …   Wikipedia

  • DNA polymerase II — This article is about the DNA Polymerase. For the RNA Polymerase, see RNA polymerase II DNA polymerase II (also known as DNA Pol II or Pol II) is a prokaryotic DNA polymerase most likely involved in DNA repair. The enzyme is 90 kDa in size and is …   Wikipedia

  • DNA polymerase — Enzyme that catalyzes (speeds) the polymerization of DNA. DNA polymerase uses preexisting nucleic acid templates and assembles the DNA from deoxyribonucleotides. * * * DNA polymerase n any of several polymerases that promote replication or repair …   Medical dictionary

  • DNA polymerase — noun the enzyme responsible for DNA replication • Hypernyms: ↑polymerase * * * noun : any of several polymerases that promote replication or repair of DNA usually using single stranded DNA as a template * * * any of a class of enzymes involved in …   Useful english dictionary