DGCR5 (gene)

DiGeorge syndrome critical region gene 5 (non-protein coding)
Identifiers
Symbols	DGCR5; KIAA1647; NCRNA00037
External IDs	GeneCards: DGCR5 Gene
Gene Ontology
Orthologs
Species	Human	Mouse
Entrez	26220	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	NR_002733	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	[1]	n/a

In molecular biology, DiGeorge syndrome critical region gene 5 (non-protein coding), alsoknown as DGCR5, is a long non-coding RNA. In humans, it is located on chromosome 22q11, at the ADU breakpoint associated with DiGeorge syndrome.^[1] Its expression is regulated by the transcription factor REST (RE1-Silencing Transcription factor).^[2]

See also

• Long noncoding RNA

References

1. ^ Sutherland, H. F.; Wadey, R.; McKie, J. M.; Taylor, C.; Atif, U.; Johnstone, K. A.; Halford, S.; Kim, U. J. et al. (1996). "Identification of a novel transcript disrupted by a balanced translocation associated with DiGeorge syndrome". American journal of human genetics 59 (1): 23–31. PMC 1915101. PMID 8659529. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1915101.  edit
2. ^ Johnson, R.; Teh, C. H. -L.; Jia, H.; Vanisri, R. R.; Pandey, T.; Lu, Z. -H.; Buckley, N. J.; Stanton, L. W. et al. (2008). "Regulation of neural macroRNAs by the transcriptional repressor REST". RNA 15 (1): 85–96. doi:10.1261/rna.1127009. PMC 2612765. PMID 19050060. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2612765.  edit

Further reading

• Hirosawa M, Nagase T, Murahashi Y, et al. (2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping.". DNA Res. 8 (1): 1–9. doi:10.1093/dnares/8.1.1. PMID 11258795.