- Aminolevulinic acid
δ-Aminolevulinic acid Systematic (IUPAC) name 5-amino-4-oxo-pentanoic acid Clinical data Pregnancy cat. ? Legal status ? Identifiers CAS number ATC code L01 PubChem DrugBank ChemSpider UNII KEGG ChEBI ChEMBL Chemical data Formula C5H9NO3 Mol. mass 131.13 g/mol SMILES & (what is this?)
In plants, production of δ-ALA is the step on which the speed of synthesis of chlorophyll is regulated. Plants that are fed by external δ-ALA accumulate toxic amounts of chlorophyll precursor, protochlorophyllide, indicating that the synthesis of this intermediate is not suppressed anywhere downwards in the chain of reaction. Protochlorophyllide is a strong photosensitizer in plants.
In non-photosynthetic eukaryotes such as animals, insects, fungi, and protozoa, as well as the α-proteobacteria group of bacteria, it is produced by the enzyme ALA synthase, from glycine and succinyl CoA. This reaction is known as the Shemin pathway.
In plants, algae, bacteria (except for the α-proteobacteria group) and archaea, it is produced from glutamic acid via glutamyl-tRNA and glutamate-1-semialdehyde. The enzymes involved in this pathway are glutamyl-tRNA synthetase, glutamyl-tRNA reductase, and glutamate-1-semialdehyde aminotransferase. This pathway is known as the C5 or Beale pathway.
It elicits synthesis and accumulation of fluorescent porphyrins (protoporphyrin IX) in epithelia and neoplastic tissues, among them malignant gliomas. It is used to visualise tumorous tissue in neurosurgical procedures. Studies have shown that the intraoperative use of this guiding method may reduce the tumour residual volume and prolong progression-free survival in patients suffering from this disease.
Photodynamic detection (PDT) is the use of photosensitive drugs with a light source of the right wavelength for the detection of cancer, using fluorescence of the drug. PDT treatment possibilities include those for cancer of the prostate, breast, giant BCC (skin), cervix, recurrent bladder, vulvar, brain (human glioblastoma cells), HPV, lung, stomach, head and neck, penis, and colon, as well as those for leukemia, Barrett's oesophagus, squamous cell carcinoma (SCC), Bowen's disease, and other types of cancer.
- ^ Beale, Samuel I. (1990) Biosynthesis of the tetrapyrrole pigment precursor, d-aminolevulinic acid, from glutamate. Plant Physiology, 93(4), 1273-1279
- ^ Willows R.D. (2004) Chlorophylls In: Encyclopaedia of Plant and Crop Science. pp 258-262, Ed: Robert M. Goodman. Marcel Dekker Inc, ISBN 0-8247-4268-0
- ^ Stummer W, Pichlmeier U, Meinel T, Wiestler OD, Zanella F, Reulen HJ (2006). "Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial". Lancet Oncol. 7 (5): 392–401. doi:10.1016/S1470-2045(06)70665-9. PMID 16648043.
Intracellular chemotherapeutic agents/antineoplastic agents (L01) SPs/MIs
(M phase)Block microtubule assemblyBlock microtubule disassembly
inhibitorIIICrosslinking of DNA
(CCNS)Aziridines: Carboquone • ThioTEPA • Triaziquone • Triethylenemelamine
Photosensitizers/PDT OtherOther/ungroupedAmsacrine • Trabectedin • retinoids (Alitretinoin, Tretinoin) • Arsenic trioxide • asparagine depleters (Asparaginase/Pegaspargase) • Celecoxib • Demecolcine • Elesclomol • Elsamitrucin • Etoglucid • Lonidamine • HAMLET (human alpha-lactalbumin made lethal to tumor cells) • Lucanthone • Mitoguazone • Mitotane • Oblimersen • Omacetaxine mepesuccinate • mTOR inhibitors (Everolimus, Temsirolimus)
tumr, epon, para
Porphyrin biosynthesis Heme degradation
and excretionBreakdown of hemeIntestine, excretion in fecesKidney, excretion in urine
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См. также в других словарях:
aminolevulinic acid — noun Any amino derivative of levulinic acid, but especially 5 aminolevulinic acid which is an intermediate in the biosynthesis of porphyrin … Wiktionary
aminolevulinic acid — (ALA) ami·no·lev·u·lin·ic ac·id (ALA) (ə me″no lev″u linґik) δ aminolevulinic acid; an intermediate in the synthesis of heme, produced from succinyl CoA and glycine. Two molecules of ALA are condensed to form porphobilinogen … Medical dictionary
aminolevulinic acid — A drug used to treat a precancerous skin condition called actinic keratosis. It is also being studied in the treatment of skin cancer and other types of cancer. When absorbed by abnormal cells and exposed to light, aminolevulinic acid becomes… … English dictionary of cancer terms
Aminolevulinic acid dehydratase deficiency porphyria — (also known as Doss porphyria,  and Plumboporphyria ) is a cutaneous condition, disease can present during early childhood (as well as in adulthood) with acute neurologic symptoms that resemble those encountered in acute intermittent… … Wikipedia
Aminolevulinic acid synthase — protein Name = aminolevulinate, delta , synthase 1 caption = width = HGNCid = 396 Symbol = ALAS1 AltSymbols = ALAS3, ALAS EntrezGene = 211 OMIM = 125290 RefSeq = NM 000688 UniProt = P13196 PDB = ECnumber = 220.127.116.11 Chromosome = 3 Arm = p Band =… … Wikipedia
aminolevulinic acid hydrochloride — the hydrochloride salt of aminolevulinic acid, applied topically in the treatment of nonhyperkeratotic actinic keratoses of the face and scalp. It is metabolized to protoporphyrin IX, a photosensitizer, which accumulates in the skin at the sites… … Medical dictionary
D-Aminolevulinic acid — (dALA or δ ALA or 5 aminolevulinic acid) is the first compound in the porphyrin synthesis pathway, the pathway that leads to hemoglobin in mammals.In non photosynthetic eukaryotes such as animals, insects, fungi, and protozoa, as well as the α… … Wikipedia
δ-aminolevulinic acid — An acid formed by δ aminolevulinate synthase from glycine and succinyl coenzyme A; a precursor of porphobilinogen, hence an important intermediate in the biosynthesis of heme. ALA levels are elevated in cases of lead poisoning. δ aminolevulinic… … Medical dictionary
aminolevulinic — adjective Of or pertaining to aminolevulinic acid or its derivatives … Wiktionary
α-amino-β-ketoadipic acid — An intermediate of porphobilinogen synthesis formed by δ aminolevulinic acid synthase from succinyl CoA and glycine; it rapidly decarboxylates to δ aminolevulinic acid … Medical dictionary