Cytidine deaminase

Cytidine deaminase
Cytidine deaminase

PDB rendering based on 1mq0.
Identifiers
Symbols CDA; CDD
External IDs OMIM123920 MGI1919519 HomoloGene1352 GeneCards: CDA Gene
EC number 3.5.4.5
RNA expression pattern
PBB GE CDA 205627 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 978 72269
Ensembl ENSG00000158825 ENSMUSG00000028755
UniProt P32320 Q8R219
RefSeq (mRNA) NM_001785 NM_028176.1
RefSeq (protein) NP_001776 NP_082452.1
Location (UCSC) Chr 1:
20.92 – 20.95 Mb
Chr 4:
137.89 – 137.92 Mb
PubMed search [1] [2]

Cytidine deaminase is an enzyme that in humans is encoded by the CDA gene.[1][2][3]

This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias.[3]


Interactive pathway map

Click on genes, proteins and metabolites below to link to respective Wikipedia articles. [4]

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FluoropyrimidineActivity_WP1601 go to article go to article go to article go to article go to article go to article go to article go to article start new article go to article go to article go to article go to article start new article go to article start new article go to article go to article go to article go to article go to article go to article start new article go to article go to article go to article go to article go to article Go to HMDB Go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article
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FluoropyrimidineActivity_WP1601 go to article go to article go to article go to article go to article go to article go to article go to article start new article go to article go to article go to article go to article start new article go to article start new article go to article go to article go to article go to article go to article go to article start new article go to article go to article go to article go to article go to article Go to HMDB Go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article
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Fluorouracil (5-FU) Activity edit

References

  1. ^ Kuhn K, Bertling WM, Emmrich F (Feb 1993). "Cloning of a functional cDNA for human cytidine deaminase (CDD) and its use as a marker of monocyte/macrophage differentiation". Biochem Biophys Res Commun 190 (1): 1–7. doi:10.1006/bbrc.1993.1001. PMID 8422236. 
  2. ^ Demontis S, Terao M, Brivio M, Zanotta S, Bruschi M, Garattini E (Feb 1999). "Isolation and characterization of the gene coding for human cytidine deaminase". Biochim Biophys Acta 1443 (3): 323–33. PMID 9878810. 
  3. ^ a b "Entrez Gene: CDA cytidine deaminase". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=978. 
  4. ^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601". http://www.wikipathways.org/index.php/Pathway:WP1601. 

Further reading



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