Cyclin D3

Cyclin D3
Cyclin D3
Symbols CCND3;
External IDs OMIM123834 MGI88315 HomoloGene20419 GeneCards: CCND3 Gene
RNA expression pattern
PBB GE CCND3 201700 at tn.png
More reference expression data
Species Human Mouse
Entrez 896 12445
Ensembl ENSG00000112576 ENSMUSG00000034165
UniProt P30281 Q3TSW4
RefSeq (mRNA) NM_001136017.2 XM_001003930
RefSeq (protein) NP_001129489.1 XP_001003930
Location (UCSC) Chr 6:
41.9 – 42.02 Mb
Chr 17:
47.64 – 47.74 Mb
PubMed search [1] [2]

G1/S-specific cyclin-D3 is a protein that in humans is encoded by the CCND3 gene.[1]

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation.[2]

See also


Cyclin D3 has been shown to interact with Retinoic acid receptor alpha,[3] AKAP8,[4] CDC2L1,[5] CRABP2,[3] Cyclin-dependent kinase 4,[4][6][7][8] Cyclin-dependent kinase 6,[7][9] EIF3K[10] and CDKN1B.[6][7][8]


  1. ^ Inaba T, Matsushime H, Valentine M, Roussel MF, Sherr CJ, Look AT (Aug 1992). "Genomic organization, chromosomal localization, and independent expression of human cyclin D genes". Genomics 13 (3): 565–74. doi:10.1016/0888-7543(92)90126-D. PMID 1386335. 
  2. ^ "Entrez Gene: CCND3 cyclin D3". 
  3. ^ a b Despouy, Gilles; Bastie Jean-Nöel, Deshaies Sylvie, Balitrand Nicole, Mazharian Alexandra, Rochette-Egly Cécile, Chomienne Christine, Delva Laurent (Feb. 2003). "Cyclin D3 is a cofactor of retinoic acid receptors, modulating their activity in the presence of cellular retinoic acid-binding protein II". J. Biol. Chem. (United States) 278 (8): 6355–62. doi:10.1074/jbc.M210697200. ISSN 0021-9258. PMID 12482873. 
  4. ^ a b Arsenijevic, Tatjana; Degraef Chantal, Dumont Jacques E, Roger Pierre P, Pirson Isabelle (Mar. 2004). "A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95". Biochem. J. (England) 378 (Pt 2): 673–9. doi:10.1042/BJ20031765. PMC 1223988. PMID 14641107. 
  5. ^ Zhang, Songwen; Cai Mingmei, Zhang Si, Xu Songli, Chen She, Chen Xiaoning, Chen Chun, Gu Jianxin (Sep. 2002). "Interaction of p58(PITSLRE), a G2/M-specific protein kinase, with cyclin D3". J. Biol. Chem. (United States) 277 (38): 35314–22. doi:10.1074/jbc.M202179200. ISSN 0021-9258. PMID 12082095. 
  6. ^ a b Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  7. ^ a b c Lin, J; Jinno S, Okayama H (Apr. 2001). "Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence". Oncogene (England) 20 (16): 2000–9. doi:10.1038/sj.onc.1204375. ISSN 0950-9232. PMID 11360184. 
  8. ^ a b Zhang, Q; Wang X, Wolgemuth D J (Jun. 1999). "Developmentally regulated expression of cyclin D3 and its potential in vivo interacting proteins during murine gametogenesis". Endocrinology (UNITED STATES) 140 (6): 2790–800. doi:10.1210/en.140.6.2790. ISSN 0013-7227. PMID 10342870. 
  9. ^ Meyerson, M; Harlow E (Mar. 1994). "Identification of G1 kinase activity for cdk6, a novel cyclin D partner". Mol. Cell. Biol. (UNITED STATES) 14 (3): 2077–86. ISSN 0270-7306. PMC 358568. PMID 8114739. 
  10. ^ Shen, Xiaoyun; Yang Yanzhong, Liu Weicheng, Sun Maoyun, Jiang Jianhai, Zong Hongliang, Gu Jianxin (Aug. 2004). "Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3". FEBS Lett. (Netherlands) 573 (1-3): 139–46. doi:10.1016/j.febslet.2004.07.071. ISSN 0014-5793. PMID 15327989. 

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