Cyclin A1

Cyclin A1
Cyclin A1
Symbols CCNA1;
External IDs OMIM604036 MGI108042 HomoloGene31203 GeneCards: CCNA1 Gene
RNA expression pattern
PBB GE CCNA1 205899 at tn.png
More reference expression data
Species Human Mouse
Entrez 8900 12427
Ensembl ENSG00000133101 ENSMUSG00000027793
UniProt P78396 Q8C5U1
RefSeq (mRNA) NM_001111045.1 NM_007628.3
RefSeq (protein) NP_001104515.1 NP_031654.2
Location (UCSC) Chr 13:
37.01 – 37.02 Mb
Chr 3:
54.85 – 54.86 Mb
PubMed search [1] [2]

Cyclin-A1 is a protein that in humans is encoded by the CCNA1 gene.[1]

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell division cycle. Cyclins function as activating subunits of enzymatic complex together with cyclin-dependent kinases (CDKs). Different cyclins exhibit distinct expression and degradation patterns that contribute to the temporal coordination of cell cycle events. Cyclin A1 was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of meiosis. This cyclin binds both Cdk1 and Cdk2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F1, and the Kip/Cip family of CDK-inhibitor proteins.[2]


Cyclin-A1 interacts with E2F1,[3] CDC20,[4] Retinoblastoma protein,[3] Cyclin-dependent kinase 2,[1][5][6][7] GPS2,[8] MYBL2[6] and GNB2L1.[8]


  1. ^ a b Yang R, Morosetti R, Koeffler HP (Mar 1997). "Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines". Cancer Res 57 (5): 913–20. PMID 9041194. 
  2. ^ "Entrez Gene: CCNA1 cyclin A1". 
  3. ^ a b Yang, R; Müller C, Huynh V, Fung Y K, Yee A S, Koeffler H P (Mar. 1999). "Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins". Mol. Cell. Biol. (UNITED STATES) 19 (3): 2400–7. ISSN 0270-7306. PMC 84032. PMID 10022926. 
  4. ^ Ohtoshi, A; Maeda T, Higashi H, Ashizawa S, Hatakeyama M (Feb. 2000). "Human p55(CDC)/Cdc20 associates with cyclin A and is phosphorylated by the cyclin A-Cdk2 complex". Biochem. Biophys. Res. Commun. (UNITED STATES) 268 (2): 530–4. doi:10.1006/bbrc.2000.2167. ISSN 0006-291X. PMID 10679238. 
  5. ^ Sweeney, C; Murphy M, Kubelka M, Ravnik S E, Hawkins C F, Wolgemuth D J, Carrington M (Jan. 1996). "A distinct cyclin A is expressed in germ cells in the mouse". Development (ENGLAND) 122 (1): 53–64. ISSN 0950-1991. PMID 8565853. 
  6. ^ a b Müller-Tidow, C; Wang W, Idos G E, Diederichs S, Yang R, Readhead C, Berdel W E, Serve H, Saville M, Watson R, Koeffler H P (Apr. 2001). "Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function". Blood (United States) 97 (7): 2091–7. doi:10.1182/blood.V97.7.2091. ISSN 0006-4971. PMID 11264176. 
  7. ^ Brown, N R; Noble M E, Endicott J A, Johnson L N (Nov. 1999). "The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases". Nat. Cell Biol. (England) 1 (7): 438–43. doi:10.1038/15674. ISSN 1465-7392. PMID 10559988. 
  8. ^ a b Diederichs, Sven; Bäumer Nicole, Ji Ping, Metzelder Stephan K, Idos Gregory E, Cauvet Thomas, Wang Wenbing, Möller Maria, Pierschalski Sarah, Gromoll Jörg, Schrader Mark G, Koeffler H Phillip, Berdel Wolfgang E, Serve Hubert, Müller-Tidow Carsten (Aug. 2004). "Identification of interaction partners and substrates of the cyclin A1-CDK2 complex". J. Biol. Chem. (United States) 279 (32): 33727–41. doi:10.1074/jbc.M401708200. ISSN 0021-9258. PMID 15159402. 

Further reading

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