cAMP receptor protein

CAMP receptor protein
Structure of the E. coli Cyclic AMP Receptor Protein.
Identifiers
Symbol	CRP
Alt. symbols	CAP
Entrez	947867
PDB	1I5Z
RefSeq	NP_417816.1
UniProt	P0ACJ8
Other data

cAMP receptor protein (in short CRP, also known as catabolite gene activator protein (in short CAP)) is a regulatory protein in bacteria. This protein binds cAMP, which causes a conformational change that allows the protein to bind tightly to a specific DNA sequence in the promoters of the genes it controls.^[1] The genes regulated by this protein are mostly involved in energy metabolism, such as galactose, citrate, or the PEP group translocation system.^[2][3]

References

1. ^ Harman JG (2001). "Allosteric regulation of the cAMP receptor protein". Biochim. Biophys. Acta 1547 (1): 1–17. doi:10.1016/S0167-4838(01)00187-X. PMID 11343786. 
2. ^ Weickert MJ, Adhya S (1993). "The galactose regulon of Escherichia coli". Mol. Microbiol. 10 (2): 245–51. doi:10.1111/j.1365-2958.1993.tb01950.x. PMID 7934815. 
3. ^ Bott M (1997). "Anaerobic citrate metabolism and its regulation in enterobacteria". Arch. Microbiol. 167 (2–3): 78–88. doi:10.1007/s002030050419. PMID 9133329. 

External links

• crystal structure of CRP and binding site properties

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