Corneal dystrophy of Bowman layer, type II

Corneal dystrophy of Bowman layer, type II
Corneal dystrophy of Bowman layer, type II
Classification and external resources
OMIM 602082

Corneal dystrophy of Bowman layer, type II (CDB2), or, more commonly, Thiel-Behnke dystrophy (TBCD), is a rare form of human corneal dystrophy affecting the layer that supports corneal epithelium. Some cases of it are linked to chromosome 10q24, others stem from a mutation in the TGFBI gene.

The dystrophy was first described in 1967[1] and initially suspected to denote the same entity as the earlier-described Reis-Bucklers dystrophy, but following a study in 1995 by Kuchle et al. the two look-alike dystrophies were deemed separate disorders.[2]

References

  1. ^ Thiel HJ, Behnke H (1967). "[A hitherto unknown subepithelial hereditary corneal dystrophy]" (in German). Klin Monatsbl Augenheilkd 150 (6): 862–74. PMID 5301630. 
  2. ^ Küchle M, Green WR, Völcker HE, Barraquer J (July 1995). "Reevaluation of corneal dystrophies of Bowman's layer and the anterior stroma (Reis-Bücklers and Thiel-Behnke types): a light and electron microscopic study of eight corneas and a review of the literature". Cornea 14 (4): 333–54. doi:10.1097/00003226-199507000-00001. PMID 7671605. 
v · d · eTypes of human corneal dystrophy (H18.5, 371.5)
Epithelial and Subepithelial
Epithelial basement membrane dystrophy (OMIM 121820), called a corneal dystrophy but in reality this condition is not inherited in the majority of cases, representing a non-specific reaction to a variety of corneal insults. · Subepithelial mucinous corneal dystrophy · Meesmann juvenile epithelial corneal dystrophy (MECD, Stocker-Holt dystrophy, OMIM 122100) · Lisch epithelial dystrophy · Gelatinous drop-like corneal dystrophy
Bowman layer
Reis-Bucklers corneal dystrophy (CDB1) aka. Granular corneal dystrophy type III · Thiel-Behnke dystrophy (CDB2)
Stroma
Lattice corneal dystrophy type I · Lattice corneal dystrophy type II · Granular corneal dystrophy type I · Granular corneal dystrophy type II · Also Granular corneal dystrophy type III see Reis-Bucklers corneal dystrophy above · Macular corneal dystrophy · Schnyder corneal dystrophy · Congenital stromal dystrophy (CSCD) · Fleck dystrophy · Posterior amorphous corneal dystrophy
Descemet membrane and Endothelial
Fuchs' dystrophy · Posterior polymorphous dystrophy type 1 · Posterior polymorphous dystrophy type 2 · Posterior polymorphous dystrophy type 3 · Congenital endothelial dystrophy type 1 (CHED1) · Congenital endothelial dystrophy type 2 (CHED2) · X-linked endothelial corneal dystrophy

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