Coiled-Coil Domain Containing Protein

Coiled-Coil Domain Containing Protein
coiled-coil domain containing 25
Symbols CCDC25; FLJ10853
External IDs MGI1914429 HomoloGene6645 GeneCards: CCDC25 Gene
Species Human Mouse
Entrez 55246 67179
Ensembl ENSG00000147419 ENSMUSG00000022035
UniProt n/a n/a
RefSeq (mRNA) NM_018246 NM_145944
RefSeq (protein) NP_060716 NP_666056
Location (UCSC) Chr 8:
27.65 – 27.69 Mb
Chr 14:
66.46 – 66.49 Mb
PubMed search [1] [2]

The Coiled-Coil Domain Containing Protein – 25 (CCDC25) is a human protein whose function is not presently understood.



The gene encoding the CCDC25 protein is located at 8p21.1, on the short arm of human chromosome eight,[1] and is transcribed into an mRNA product approximately 3,583 nucleotides in length.



The protein is highly conserved among mammals as well as eukaryotes as diverse as Arabidopsis thaliana. CCDC25 is made up of a single polypeptide chain 208 amino acids in length and is expressed at a high level, nearly 4.2 times that of a normal human protein.[2] Its expression is nearly ubiquitous in human tissues with little indication that its expression level changes drastically in diseased tissues.[1] Despite currently lacking a well understood function, CCDC25 is predicted to localize to the nucleus[2] and was shown by a microarray experiment to be upregulated in Metaphase II oocytes.[3]


CCDC25 was shown by a yeast-two-hybrid assay to interact with Smad2, a latent transcription factor that is part of the TGF-ß signaling pathway.[4] The protein is a predicted substrate of Casein Kinase 1, Casein Kinase 2, cGMP-dependent protein kinase, and the Insulin Receptor; all of which have well defined roles in cell signaling.


Further reading

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См. также в других словарях:

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  • PDZ domain — Molecular structure of the PDZ domain included in the human GOPC (Golgi associated PDZ and coiled coil motif containing protein) protein Identifiers Symbol PDZ …   Wikipedia

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  • CCDC5 — Coiled coil domain containing 5 (spindle associated), also known as CCDC5, is a human gene.cite web | title = Entrez Gene: CCDC5 coiled coil domain containing 5 (spindle associated)| url =… …   Wikipedia

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  • CCDC53 — Coiled coil domain containing 53, also known as CCDC53, is a human gene.cite web | title = Entrez Gene: CCDC53 coiled coil domain containing 53| url = Cmd=ShowDetailView TermToSearch=51019|… …   Wikipedia

  • CCDC55 (gene) — Coiled coil domain containing 55, also known as CCDC55, is a human gene.cite web | title = Entrez Gene: CCDC55 coiled coil domain containing 55| url = Cmd=ShowDetailView TermToSearch=84081|… …   Wikipedia

  • CCDC50 — Coiled coil domain containing 50, also known as CCDC50, is a human gene.cite web | title = Entrez Gene: CCDC50 coiled coil domain containing 50| url = Cmd=ShowDetailView TermToSearch=152137|… …   Wikipedia

  • CCDC113 — Coiled coil domain containing 113, also known as CCDC113, is a human gene.cite web | title = Entrez Gene: CCDC113 coiled coil domain containing 113| url = Cmd=ShowDetailView TermToSearch=29070|… …   Wikipedia

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