- Comprehensive information about Lomotil and allied drugs is under the article Diphenoxylate.
Co-phenotrope Combination of Diphenoxylate mu opiate receptor agonist Atropine muscarinic acetylcholine receptors antagonist Clinical data Pregnancy cat. ? Legal status POM (UK) Schedule V (US) Routes Oral Identifiers ATC code ? ChemSpider (what is this?)
Its active ingredients are diphenoxylate and atropine. Diphenoxylate is anti-diarrheal and atropine is anticholinergic. Diphenoxylate is chemically related to the opioid drug meperidine. A subtherapeutic amount of atropine sulfate is present to discourage deliberate overdosage. Atropine has no anti-diarrheal properties, but will cause tachycardia when overused. The medication diphenoxylate works by slowing down the movement of the intestines.
Other trade names for the same therapeutic combination are Lofene, Logen, Lomanate and Lonox, among others. In other countries, Lomotil may have other names.
Absolute contraindications for Lomotil are:
- Allergy to diphenoxylate or atropine
- Presence of jaundice
- Diarrhea associated with pseudomembranous enterocolitis, diarrhea caused by antibiotic treatment, or diarrhea caused by enterotoxin-producing bacteria.
Interactions with other drugs:
- Antidepressants (e.g., Elavil, Prozac, Paxil)
- Tranquilizers (e.g., Valium, Xanax, Klonopin)
- Monoamine oxidase inhibitors (e.g., Nardil, Parnate)
The drug combination is generally safe in short-term use and with recommended dosage. Long-term use may present problems of mild drug dependency. The dosage should be reduced after 48 h.
Lomotil may cause several side-effects, such as dry mouth, headache, constipation and blurred vision. Since it may also cause drowsiness or dizziness, Lomotil should not be used by motorists, operators of hazardous machinery, etc. It is not recommended for children under two years of age. In rare cases lomotil may cause paresthesia.
Lomotil may cause serious health problems when overdosed. Signs and symptoms of adverse effects may include any or several of the following: convulsions, respiratory depression (slow or stopped breathing), dilated eye pupils, nystagmus (rapid side-to-side eye movements), erythema (flushed skin), gastrointestinal constipation, nausea, vomiting, paralytic ileus, tachycardia (rapid pulse), drowsiness, coma and hallucinations. Symptoms of toxicity may take up to 12 hours to appear.
Treatment of Lomotil overdose must be initiated immediately after diagnosis and may include the following: emesis (induced vomiting), gastric lavage, ingestion of activated charcoal, laxative and a counteracting medication (narcotic antagonist).
Prompt and thorough treatment of overdose leads to a favorable outcome. After a narcotic antagonist is given, recovery is usually within 24 to 48 hours. Children are at risk of a very poor outcome and must be kept for observation.
- Diphenoxylate and Atropin. RxList.
- Lomotil overdose. MedlinePlus Medical Encyclopedia. Public domain.
Antidiarrheals, intestinal anti-inflammatory/anti-infective agents (A07) Rehydration Intestinal anti-infectives
Arsenical (Acetarsol)Oxyquinoline (Broxyquinoline)
Intestinal adsorbents Antipropulsives (opioids) Intestinal anti-inflammatory agents Antidiarrheal micro-organisms Other antidiarrheals
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co-phenotrope — n. a drug administered by mouth in the treatment of diarrhoea. It consists of a mixture of diphenoxylate hydrochloride (an opioid that reduces peristalsis) and atropine (which relaxes the smooth muscle of the gut) in a ratio of 100 to 1. Trade… … Medical dictionary
co-phenotrope — n. a drug administered by mouth in the treatment of diarrhoea. It consists of a mixture of diphenoxylate hydrochloride (an opioid that reduces peristalsis) and atropine (which relaxes the smooth muscle of the gut) in a ratio of 100 to 1. Trade… … The new mediacal dictionary
Diarrhea — For other uses, see Diarrhea (disambiguation). Diarrhea An electron micrograph … Wikipedia
British Approved Name — A British Approved Name (BAN) is the official non proprietary or generic name given to a pharmaceutical substance, as defined in the British Pharmacopoeia (BP). The BAN is also the official name used in many countries across the world, especially … Wikipedia
Lomotil — Drugbox type = combo component1 = Diphenoxylate class1 = mu opiate receptor agonist component2 = Atropine class2 = muscarinic acetylcholine receptors antagonist CAS number = ATC prefix = ATC suffix = PubChem = DrugBank = pregnancy AU = pregnancy… … Wikipedia
diphenoxylate — di·phen·oxy·late .dī .fen äk sə .lāt n an antidiarrheal agent chemically related to meperidine and administered in the form of its hydrochloride C30H32N2O2·HCl in combination with the sulfate of atropine see LOMOTIL * * * n. see co phenotrope … Medical dictionary
Lomotil — Lo·mo·til lō mə .til, lō mōt əl trademark used for a preparation of the hydrochloride of diphenoxylate and the sulfate of atropine * * * n. see co phenotrope * * * Lo·mo·til (loґmo til) trademark for combination preparations of diphenoxylate… … Medical dictionary
diphenoxylate — n.; see co phenotrope … The new mediacal dictionary
Lomotil — n.; see co phenotrope … The new mediacal dictionary