Cinobufagin

Cinobufagin: Cinobufagin

Other names

Cinobufagin

Identifiers

CAS number 470-37-1^Y

PubChem 10103

ChEMBL CHEMBL250785^N

Jmol-3D images Image 1

SMILES

CC(=O)O[C@@H]1[C@@H](C2(CCC3C([C@@]24[C@@H]1O4)CC[C@H]5C3(CC[C@@H](C5)O)C)C)C6=CC(=O)OC=C6

Properties

Molecular formula C₂₆H₃₄O₆

Molar mass 442.54 g mol⁻¹

Hazards

Main hazards Toxic

N (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)

Infobox references

Cinobufagin is a cardiotoxic bufanolide steroid secreted by the Asiatic toad Bufo gargarizans. It has similar effects to digitalis and is used in traditional Chinese medicine.^[1]

References

^ Yang Z, Luo H, Wang H, Hou H. Preparative isolation of bufalin and cinobufagin from Chinese traditional medicine Chan Su. Journal of Chromatographic Science. 2008 Jan;46(1):81-5. PMID 18218193

v · d · eToxins (enterotoxin/neurotoxin/hemotoxin/cardiotoxin/phototoxin)

Bacterial toxins

Exotoxin

Gram positive

Bacilli

Clostridium: tetani (Tetanospasmin) · perfringens (Alpha toxin, Enterotoxin) · difficile (A, B) · botulinum (Botox)
other: Anthrax toxin · Listeriolysin O

Cocci

Streptolysin · Leukocidin (Panton-Valentine leukocidin) · Staphylococcus (Staphylococcus aureus alpha/beta/delta, Exfoliatin, Toxic shock syndrome toxin, SEB)

Actinobacteria

Cord factor · Diphtheria toxin

Gram negative

Shiga toxin · Verotoxin/shiga-like toxin (E. coli) · E. coli heat-stable enterotoxin/enterotoxin · Cholera toxin · Pertussis toxin · Pseudomonas exotoxin · Extracellular adenylate cyclase

By mechanism

type I (Superantigen) · type II (Pore forming toxins) · type III (AB toxin/AB5)

Endotoxin

Lipopolysaccharide (Lipid A) · Bacillus thuringiensis delta endotoxin

Virulence factor

Clumping factor A · Fibronectin binding protein A

Mycotoxins
Aflatoxin · Amatoxin (alpha-amanitin, beta-amanitin, gamma-amanitin, epsilon-amanitin) · Citrinin · Cytochalasin · Ergotamine · Fumonisin (Fumonisin B1, Fumonisin B2) · Gliotoxin · Ibotenic acid · Muscimol · Ochratoxin · Patulin · Phalloidin · Sterigmatocystin · Trichothecene · Vomitoxin · Zeranol · Zearalenone

Invertebrates
arthropod: scorpion: Charybdotoxin, Maurotoxin, Agitoxin, Margatoxin, Slotoxin, Scyllatoxin, Hefutoxin, Lq2, Birtoxin, Bestoxin, BmKAEP, Phaiodotoxin · spider: Latrotoxin (Alpha-latrotoxin) · Stromatoxin · PhTx3
mollusca: Conotoxin · Eledoisin · Onchidal · Saxitoxin · Tetrodotoxin

Vertebrates

fish: Ciguatera · Tetrodotoxin

amphibian: (+)-Allopumiliotoxin 267A · Batrachotoxin · Bufotoxins (Arenobufagin, Bufotalin, Bufotenin · Cinobufagin, Marinobufagin) · Epibatidine · Histrionicotoxin · Pumiliotoxin 251D · Tarichatoxin
reptile/snake venom: Bungarotoxin (Alpha-Bungarotoxin, Beta-Bungarotoxin) · Calciseptine · Taicatoxin · Calcicludine · Cardiotoxin III

note: some toxins are produced by lower species and pass through intermediate species

M: TOX

gen / txn

pto

ant

v · d · eCardiac glycosides (C01A)

Bufadienolides

Bufo

Arenobufagin • Bufotalin • Cinobufagin • Marinobufagin

Scilla

Proscillaridin • Scilliroside

Cardenolides

Digitalis

Acetyldigitoxin • Acetyldigoxin • Digitoxin^# • Digoxin • Lanatoside C • Deslanoside • Metildigoxin • Gitoformate

Kalanchoe

Daigremontianin

Strophantus

Ouabain (g-Strophanthin) • k-Strophanthin • Cymarin

Thevetia

Peruvoside

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III

M: HRT

anat/phys/devp

noco/cong/tumr, sysi/epon, injr

proc, drug (C1A/1B/1C/1D), blte

Categories:
Vertebrate toxins
Epoxides
Bufanolides
Alcohols
Acetate esters
Toxicology stubs
Biochemistry stubs

Cinobufagin

Other names Cinobufagin
Identifiers
CAS number	470-37-1^Y
PubChem	10103
ChEMBL	CHEMBL250785^N
Jmol-3D images	Image 1
SMILES CC(=O)O[C@@H]1[C@@H](C2(CCC3C([C@@]24[C@@H]1O4)CC[C@H]5C3(CC[C@@H](C5)O)C)C)C6=CC(=O)OC=C6
Properties
Molecular formula	C₂₆H₃₄O₆
Molar mass	442.54 g mol⁻¹
Hazards
Main hazards	Toxic
N (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

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Look at other dictionaries:

cinobufagin — cin·o·bufagin … English syllables
cinobufagin — ˌsinə, ˌsīnə+ noun Etymology: cino (probably from New Latin Bufo chinensis, species of toad from which senso is produced) + bufagin : a bufagin C26H34O6 obtained from senso … Useful english dictionary
Bufagin — Bufagins are a class of toxic steroids found as components of bufotoxin. They can be obtained (in form of marinobufagin, for example) from toad s milk, which refers to secretions from the Cane Toad ( Bufo marinus ), when it is injured, scared or… … Wikipedia
Marinobufagenin — Other names Marinobufagin, Marinobufagenin Identifiers … Wikipedia
Toxin — This article is about the class of poisonous substances. For other uses, see Toxin (disambiguation). Universal warning symbol used to indicate toxic substances or environments A toxin (from Ancient Greek: τοξικόν toxikon) is a poisonous… … Wikipedia
Botulinum toxin — Clinical data Pregnancy cat. ? Legal status ? (US) Rout … Wikipedia
Neurotoxin — A neurotoxin is a toxin that acts specifically on nerve cells[1] (neurons), usually by interacting with membrane proteins such as ion channels. Some sources are more general, and define the effect of neurotoxins as occurring at nerve tissue.[2]… … Wikipedia
Digoxin — Not to be confused with Dioxin. Digoxin Systematic (IUPAC) name 4 [(3S,5R,8R,9S,10S,12R,13S,14S) 3 [(2S,4S,5R,6R) 5 [(2S,4S,5R,6R) 5 [(2S,4S,5R,6R) 4,5 dihydroxy 6 methyl oxan 2 yl]oxy 4 hydroxy 6 methyl oxan 2 yl … Wikipedia
Digitoxin — Systematic (IUPAC) name (3β,5β) 3 [(O 2,6 dideoxy β D ribo hexapyranosyl (1 >4) 2,6 dideoxy β D ribo hexopyranosyl)oxy] 14 hydroxycard 20(22) enolide Clinical data … Wikipedia
Lipopolysaccharide — Structure of a lipopolysaccharide Lipopolysaccharides (LPS), also known as lipoglycans, are large molecules consisting of a lipid and a polysaccharide joined by a covalent bond; they are found in the outer membrane of Gram negative bacteria, act… … Wikipedia

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Cinobufagin

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