Actin, alpha 1

Actin, alpha 1
Actin, alpha 1, skeletal muscle

PDB rendering based on 1atn.
Identifiers
Symbols ACTA1; ACTA; ASMA; CFTD; CFTD1; CFTDM; MPFD; NEM1; NEM2; NEM3
External IDs OMIM102610 MGI87902 HomoloGene121702 GeneCards: ACTA1 Gene
RNA expression pattern
PBB GE ACTA1 203872 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 58 11459
Ensembl ENSG00000143632 ENSMUSG00000031972
UniProt P68133 Q61264
RefSeq (mRNA) NM_001100.3 NM_009606.2
RefSeq (protein) NP_001091.1 NP_033736.1
Location (UCSC) Chr 1:
229.57 – 229.57 Mb
Chr 8:
126.42 – 126.42 Mb
PubMed search [1] [2]

Actin, alpha skeletal muscle is a protein that in humans is encoded by the ACTA1 gene.[1][2]

Actin alpha 1 which is expressed in skeletal muscle is one of six different actin isoforms which have been identified. Actins are highly conserved proteins that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.[3]

Contents

Skeletal actin gene expression

Skeletal alpha actin expression is induced by stimuli and conditions known to cause muscle formation.[4] Such conditions result in fusion of committed cells (satellite cells) into myotubes, to form muscle fibers. Skeletal actin itself, when expressed, causes expression of several other "myogenic genes", which are essential to muscle formation.[5] One key transcription factor that activates skeletal actin gene expression is Serum Response Factor ("SRF"), a protein that binds to specific sites on the promoter DNA of the actin gene.[6] SRF may bring a number of other proteins to the promoter of skeletal actin, such as andogen receptor, and thereby contribute to induction of skeletal actin gene expression by androgenic (often termed "anabolic") steroids.[7]

Interactions

Actin, alpha 1 has been shown to interact with TMSB4X,[8][9] MIB2[10] and PRKCE.[11]

See also

References

  1. ^ Mogensen J, Kruse TA, Borglum AD (Mar 1999). "Assignment of the human skeletal muscle [FC12]a-actin gene (ACTA1) to chromosome 1q42.13-->q42.2 by radiation hybrid mapping". Cytogenet Cell Genet 83 (3-4): 224–5. doi:10.1159/000015184. PMID 10072583. 
  2. ^ Gunning P, Ponte P, Okayama H, Engel J, Blau H, Kedes L (Aug 1983). "Isolation and characterization of full-length cDNA clones for human alpha-, beta-, and gamma-actin mRNAs: skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed". Mol Cell Biol 3 (5): 787–95. PMC 368601. PMID 6865942. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=368601. 
  3. ^ "Entrez Gene: ACTA1 actin, alpha 1, skeletal muscle". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=58. 
  4. ^ Bandman, E (1992). "Contractile protein isoforms in muscle development.". Developmental biology 154 (2): 273–83. doi:10.1016/0012-1606(92)90067-Q. PMID 1358730. 
  5. ^ Gunning, PW; Ferguson, V; Brennan, KJ; Hardeman, EC (2001). "Alpha-skeletal actin induces a subset of muscle genes independently of muscle differentiation and withdrawal from the cell cycle.". Journal of cell science 114 (Pt 3): 513–24. PMID 11171321. 
  6. ^ Belaguli, NS; Zhou, W; Trinh, TH; Majesky, MW; Schwartz, RJ (1999). "Dominant negative murine serum response factor: alternative splicing within the activation domain inhibits transactivation of serum response factor binding targets.". Molecular and cellular biology 19 (7): 4582–91. PMC 84256. PMID 10373507. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84256. 
  7. ^ Vlahopoulos, S; Zimmer, WE; Jenster, G; Belaguli, NS; Balk, SP; Brinkmann, AO; Lanz, RB; Zoumpourlis, VC et al. (2005). "Recruitment of the androgen receptor via serum response factor facilitates expression of a myogenic gene.". The Journal of biological chemistry 280 (9): 7786–92. doi:10.1074/jbc.M413992200. PMID 15623502. 
  8. ^ Ballweber, Edda; Hannappel Ewald, Huff Thomas, Stephan Harald, Haener Markus, Taschner Nicole, Stoffler Daniel, Aebi Ueli, Mannherz Hans Georg (Jan. 2002). "Polymerisation of chemically cross-linked actin:thymosin beta(4) complex to filamentous actin: alteration in helical parameters and visualisation of thymosin beta(4) binding on F-actin". J. Mol. Biol. (England) 315 (4): 613–25. doi:10.1006/jmbi.2001.5281. ISSN 0022-2836. PMID 11812134. 
  9. ^ Safer, D; Sosnick T R, Elzinga M (May. 1997). "Thymosin beta 4 binds actin in an extended conformation and contacts both the barbed and pointed ends". Biochemistry (UNITED STATES) 36 (19): 5806–16. doi:10.1021/bi970185v. ISSN 0006-2960. PMID 9153421. 
  10. ^ Takeuchi, Tamotsu; Heng Henry H Q, Ye Christine J, Liang Sheng-Ben, Iwata Jun, Sonobe Hiroshi, Ohtsuki Yuji (Oct. 2003). "Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma". Am. J. Pathol. (United States) 163 (4): 1395–404. doi:10.1016/S0002-9440(10)63497-9. ISSN 0002-9440. PMC 1868282. PMID 14507647. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1868282. 
  11. ^ England, Karen; Ashford David, Kidd Daniel, Rumsby Martin (Jun. 2002). "PKC epsilon is associated with myosin IIA and actin in fibroblasts". Cell. Signal. (England) 14 (6): 529–36. doi:10.1016/S0898-6568(01)00277-7. ISSN 0898-6568. PMID 11897493. 

External links

Further reading




Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

  • Alpha-Actinin 3 — Masse/Länge Primärstruktur 901 Aminosäuren …   Deutsch Wikipedia

  • Actin — G Actin (PDB code: 1j6z). ADP and the divalent cation are highlighted …   Wikipedia

  • Alpha catenin — protein Name= catenin (cadherin associated protein), alpha 1, 102kDa caption= width= HGNCid=2509 Symbol=CTNNA1 AltSymbols= EntrezGene=1495 OMIM=116805 RefSeq=NM 001903 UniProt=P35221 PDB= ECnumber= Chromosome=5 Arm=q Band=31.2… …   Wikipedia

  • Actin — G Aktin (PDB code: 1j6z) mit ADP und Kation F Aktin; Darstellung von 13 Aktin Untereinheiten (basierend auf dem …   Deutsch Wikipedia

  • Alpha-tubulin 3C — Tubulin, alpha 3c, also known as TUBA3C, is a human gene.cite web | title = Entrez Gene: TUBA3C tubulin, alpha 3c| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=7278| accessdate = ] PBB Summary section… …   Wikipedia

  • alpha-actinin — (= a actinin) A protein of 100 kD normally found as a dimer and that may link actin filaments end to end with opposite polarity. Originally described in the Z disc, now known to occur in stress fibres and at focal adhesions. Non muscle isoform… …   Dictionary of molecular biology

  • Actinin alpha 4 — Actinin, alpha 4, also known as ACTN4, is a human gene.cite web | title = Entrez Gene: ACTN4 actinin, alpha 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=81| accessdate = ] PBB Summary section title =… …   Wikipedia

  • Actinin, alpha 2 — Actinin, alpha 2, also known as ACTN2, is a human gene.cite web | title = Entrez Gene: ACTN2 actinin, alpha 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=88| accessdate = ] PBB Summary section title =… …   Wikipedia

  • Beta-Actin — G Aktin (PDB code: 1j6z) mit ADP und Kation F Aktin; Darstellung von 13 Aktin Untereinheiten (basierend auf dem …   Deutsch Wikipedia

  • Β-Actin — G Aktin (PDB code: 1j6z) mit ADP und Kation F Aktin; Darstellung von 13 Aktin Untereinheiten (basierend auf dem …   Deutsch Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”