Butalbital Systematic (IUPAC) name 5-(2-methylpropyl)-5-(2-propenyl)-
Clinical data AHFS/Drugs.com MedlinePlus Pregnancy cat. D(US) Legal status Schedule III (US) Routes oral Pharmacokinetic data Bioavailability 20-45% Metabolism hepatic Half-life 35 hours  Excretion renal Identifiers CAS number ATC code None PubChem DrugBank ChemSpider UNII KEGG ChEBI ChEMBL Chemical data Formula C11H16N2O3 Mol. mass 224.256 SMILES & (what is this?)
Butalbital, structure presents as 5-allyl-5-isobutylbarbituric acid, is a barbiturate with an intermediate duration of action. It has the same chemical formula as talbutal but a different structure. Butalbital is often combined with other medications, such as paracetamol (acetaminophen) or aspirin, and is commonly prescribed for the treatment of pain and headache. The various formulations combined with codeine are FDA approved for the treatment of tension headaches.
- Butalbital and paracetamol (acetaminophen) (trade names: Axocet, Bucet, Bupap, Cephadyn, Dolgic, Phrenilin, Phrenilin Forte, Sedapap)
- Butalbital, paracetamol (acetaminophen), and caffeine (trade names: Fioricet, Esgic, Esgic-Plus)
- Butalbital and aspirin (trade name: Axotal)
- Butalbital, aspirin, and caffeine (trade names Fiorinal, Fiormor, Fiortal, Fortabs, Laniroif)
- Butalbital, paracetamol (acetaminophen), caffeine, and codeine phosphate (Fioricet#3 with Codeine)
- Butalbital, aspirin, caffeine, and codeine phosphate (trade name: Fiorinal#3 with Codeine)
- Ergotamine tartrate, caffeine, butalbital, belladonna alkaloids (trade name: Cafergot-PB)
Side effects for any drug are difficult to predict, but commonly reported side effects for butalbital include:
(Rare side-effects include Stevens–Johnson syndrome, an adverse reaction to barbiturates.)
There are other potential side effects; this list should not be considered all-inclusive.
Dangers and Risks
Butalbital is a physically and psychologically addictive barbiturate. Butalbital should not be mixed with alcohol due to increased risk of intoxication, increased respiratory depression, and increased liver toxicity when it is a butalbital combination including paracetamol. Many opioid-dependent persons frequently use barbiturates as a potentiator to their normal dose of opiates in order to increase the effects, or with a less than normal dose as means of conserving their supply. Especially when used with the stronger Schedule II narcotics, suicide or accidental death occurs much more frequently than first reported with one drug alone. Use of alcohol, benzodiazepines, and other CNS-depressants often also contribute to respiratory depression, coma, and in extreme cases fatality. This is why Butalbital is frequently encountered with other deterrents dangerous in higher doses such as, almost always, Paracetamol/Aspirin and Caffeine(much like Tylenol #3, Vicodin, Percocet). There are other potential risks; this list should not be considered all-inclusive.
In Hong Kong, butalbital is regulated as a psychotropic substance. There are regulations governing the retail sale, wholesale and supply on prescription at community pharmacy.
Butalbital, or any preparation containing it, is a Schedule III CD (Controlled Drug) under the Misuse of Drugs Act 1971 as amended, but is not, nor has it been, available in the UK despite there having been calls for it to be made available on the NHS; this has been growing in recent years as more migraine sufferers have been prescribed Fioricet, Fiorinal or other preparation whilst on holiday in the USA; many have found it a far superior treatment than any available NHS or OTC treatment back home. There has consequently been a boom in the number of orders made for these preparations at online pharmacies in the US &, more commonly, Mexico (very few US Pharmacies ship to the UK, unlike the other way around). The other medicine British holidaymakers have found more effective, for the same conditions, than they would use at home is hydrocodone/paracetamol combinations, which many visitors to Florida especially were prescribed when asking for dihydrocodeine, an extremely close relative also prescribed for mild to moderate pain. The biggest difference is in the much higher pricing of medications in the US. In Scotland, unlike other parts of the UK, all prescriptions are free of any charges except Private Prescriptions. Elsewhere, there is a charge of a few pounds per item.
"Butalbital". On-line Medical Dictionary. http://cancerweb.ncl.ac.uk/cgi-bin/omd?query=butalbital&action=Search+OMD. Retrieved June 26, 2005. "Butalbital and Acetaminophen (Systemic)". MedicinePlus Drug Information. Archived from the original on December 30, 2006. http://web.archive.org/web/20061230122834/http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/202102.html. Retrieved December 31, 2006. "Controlled Substances in Schedule III". Drug Enforcement Administration. 2007. http://www.deadiversion.usdoj.gov/schedules/listby_sched/sched3.htm. Retrieved 2007-01-13.
Wikimedia Foundation. 2010.
Look at other dictionaries:
butalbital — bu·tal·bi·tal (bu talґbĭ təl) [USP] a short to intermediate acting barbiturate, used as a sedative in combination with an analgesic in the treatment of tension or migraine headache; administered orally … Medical dictionary
Butalbital — An occasionally encountered short acting barbiturate closely related to Talbutal and less closely to Aprobarbital and Secobarbital. Intoxication can result in lethargy, confusion, disorientation, and ataxia … Forensic science glossary
BUTAL — Butalbital (Medical » Physiology) … Abbreviations dictionary
Fioricet — and Esgic are brand name drugs made from a combination of butalbital (a barbiturate, 50 mg), acetaminophen (325 mg), and caffeine (40 mg). They are indicated for the treatment of tension headaches and muscle contraction headaches. Although not… … Wikipedia
Rebound headache — Rebound headaches, also known as medication overuse headaches, occur when pain medications (analgesics) are taken too frequently to relieve headache. Rebound headache can be caused by any painkiller or migraine abortive medication such as… … Wikipedia
Fiorinal — See also: Fioricet, a preparation using paracetamol (acetaminophen) instead of aspirin. Fiorinal is a combination analgesic medication consisting of aspirin, the barbiturate butalbital and caffeine. Some formulations also contain the opioid… … Wikipedia
Medication overuse headache — Classification and external resources ICD 10 G44.41, G44.83 Medication overuse headaches (MOH) , also known as rebound headaches usually occur when analgesics are taken frequently to relieve headaches. Rebound headaches frequently occur daily and … Wikipedia
Watson Pharmaceuticals — Infobox Company name = Watson Pharmaceuticals type = Public (nyse|WPI) genre = foundation = Libertyville, Illinois, USA (Spring 1984) founder = Allen Chao, Ph.D. and David Hsia, Ph.D. location city = Corona, California location country = U.S.… … Wikipedia
Opium Law — The Opium Law (or Opiumwet in Dutch) is the section of the Dutch law which covers nearly all psychotropic drugs. All non psychotropic, but prescription only drugs are covered by the Medicine Act. Contents 1 Origin and history 2 List I drugs 3… … Wikipedia
Barbiturat — Barbiturate sind Derivate der Barbitursäure, allerdings keine Salze oder Ester, wie der Name suggeriert. Die Substituenten sind allesamt mittels Knoevenagel Kondensation an das α C der Malonsäure gebunden. Barbitursäurederivate waren für viele… … Deutsch Wikipedia