Paricalcitol


Paricalcitol

Drugbox
IUPAC_name = (1"R",3"S")- 5- [2- [(1R,3a"R",7a"S")-1- [(2"R",5"S")-6-hydroxy-5,6-dimethyl-3"E"-hepten-2-yl] -
7a-methyl-2,3,3a,5,6,7-hexahydro-1"H"- inden-4-ylidene] ethylidene] -
cyclohexane-1,3-diol



CAS_number = 131918-61-1
CAS_supplemental =
ATC_prefix = A11
ATC_suffix = CC07
ATC_supplemental =
PubChem = 5281104
DrugBank =
chemical_formula =
C=27 | H=44 | O=3
molecular_weight = 416.636 g/mol
smiles =
bioavailability = N/A
protein_bound =
metabolism =
elimination_half-life =
excretion = Biliary
pregnancy_AU =
pregnancy_US =
pregnancy_category=
legal_AU =
legal_CA =
legal_UK =
legal_US =
legal_status =
routes_of_administration = Intravenous

Paricalcitol (trade name Zemplar) is an analog of calcitriol, the active form of vitamin D. It is used for the treatment of secondary hyperparathyroidism.

Mechanism of action

Like calcitriol, paricalcitol acts as an agonist for the calcitriol receptor and thus lowers the blood parathormone level.

A double-blind randomised study with 263 dialysis patients showed a significant advantage over calcitriol. After 18 weeks, all patients in the paricalcitol group had reached the target parathormone level of 100 to 300 pg/ml, versus none in the calcitriol group.

References

*Schubert-Zsilavecz, M, Wurglics, M, "Neue Arzneimittel 2005/2006".


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • paricalcitol — A substance that is being used to treat overactive parathyroid glands in patients with kidney failure. It is also being studied in the treatment of cancer. Paricalcitol belongs to the family of drugs called vitamin D analogs …   English dictionary of cancer terms

  • paricalcitol — noun An analog of calcitriol (the active form of vitamin D) that is used for the prevention and treatment of secondary hyperparathyroidism …   Wiktionary

  • paricalcitol — par·i·cal·ci·tol (par″ĭ kalґsĭ tol) [USP] a synthetic analogue of vitamin D, used for the prevention and treatment of hyperparathyroidism secondary to chronic renal failure; administered intravenously …   Medical dictionary

  • Trandolapril — Systematic (IUPAC) name (2S,3aR,7aS) 1 [(2S) 2 {[(2S) 1 ethoxy 1 oxo 4 phenylbutan 2 yl]amino}propanoyl] octahydro 1H indole 2 carboxylic acid Clinica …   Wikipedia

  • Hyperphosphatämie — Eine Hyperphosphatämie ist eine Erhöhung des Phosphatspiegels im Blut. Eine Hyperphosphatämie entsteht bei massiver Phosphatzufuhr, massiver Freisetzung von Phosphat durch Gewebszerstörung, verminderter Phosphatausscheidung bei fortgeschrittenem… …   Deutsch Wikipedia

  • Ascorbic acid — This article is about the molecular aspects of ascorbic acid. For information about its role in nutrition, see Vitamin C. L Ascorbic acid …   Wikipedia

  • Nicotinamide — IUPAC name pyridine 3 carboxamide …   Wikipedia

  • Riboflavin — Riboflavin …   Wikipedia

  • Vitamin C — This article is about ascorbic acid as a nutrient; for its chemical properties, see the article ascorbic acid; for other uses, see the disambiguation page. Vitamin C …   Wikipedia

  • Vitamin — This article is about the set of organic compounds. For the nutritional supplement preparation, see multivitamin. For the manga, see Vitamin (manga) …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.