IUPAC_name = (1"R",3"S")- 5- [2- [(1R,3a"R",7a"S")-1- [(2"R",5"S")-6-hydroxy-5,6-dimethyl-3"E"-hepten-2-yl] -
7a-methyl-2,3,3a,5,6,7-hexahydro-1"H"- inden-4-ylidene] ethylidene] -

CAS_number = 131918-61-1
CAS_supplemental =
ATC_prefix = A11
ATC_suffix = CC07
ATC_supplemental =
PubChem = 5281104
DrugBank =
chemical_formula =
C=27 | H=44 | O=3
molecular_weight = 416.636 g/mol
smiles =
bioavailability = N/A
protein_bound =
metabolism =
elimination_half-life =
excretion = Biliary
pregnancy_AU =
pregnancy_US =
legal_AU =
legal_CA =
legal_UK =
legal_US =
legal_status =
routes_of_administration = Intravenous

Paricalcitol (trade name Zemplar) is an analog of calcitriol, the active form of vitamin D. It is used for the treatment of secondary hyperparathyroidism.

Mechanism of action

Like calcitriol, paricalcitol acts as an agonist for the calcitriol receptor and thus lowers the blood parathormone level.

A double-blind randomised study with 263 dialysis patients showed a significant advantage over calcitriol. After 18 weeks, all patients in the paricalcitol group had reached the target parathormone level of 100 to 300 pg/ml, versus none in the calcitriol group.


*Schubert-Zsilavecz, M, Wurglics, M, "Neue Arzneimittel 2005/2006".

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