- Hydroxypropyl cellulose
Hydroxypropyl cellulose (HPC) (cellulose, 2-hydroxypropyl ether) is a derivative of
cellulosewith both water solubility and organic solubility.
Hydroxypropyl cellulose is an
ether of cellulosewhere some of the hydroxyl groups of the cellulose have been hydroxypropylated forming -OCH2CH(OH)CH3 groups. The average number of hydroxyl groups in the glucosering substituted is referred to as the degree of substitution (DS).Complete substitution would provide a DS of 3.0. Because the hydroxypropyl group added contains a hydroxyl group, this can also be etherified during preparation of hydroxypropyl cellulose. When this occurs, the number of moles of hydroxypropyl groups per glucose ring ( moles of substitution- MS) can be higher than 3.Because of the fact that cellulose is very crystalline HPC must have an MS about 4 in order to reach a good solubility in water. HPC has a combination of hydrophobicand hydrophilicgroups, so it has a Lower critical solution temperature(LCST) at 45°C: under the LCST HPC is readily soluble in water, over 45°C HPC is not soluble.An interesting property of HPC is the fact that forms liquid crystalsand many mesophases according to its concentration in water. Such mesophases include isotropic, anisotropic, nematicand cholesteric.The last one gives many colors, like violet, green and red.
CAS registry numberof hydroxypropyl cellulose is 9004-64-2.
Lacrisert, manufactured by Aton Pharma, Inc., is a formulation of it used for artificial
tears. It is used in syndromes of insufficient tear production ( keratoconjunctivitis sicca), recurrent corneal erosions, decreased corneal sensitivity, exposure and neuroparalytic keratitis, and as a lubricant for artificial eyes.
food additive, hydroxypropyl cellulose is used as a thickenerand as an emulsionstabiliser with E numberE463.
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Look at other dictionaries:
hydroxypropyl cellulose — hy·droxy·pro·pyl cel·lu·lose (hi drok″se proґpəl selґu lōs) [NF] a partially substituted, water soluble cellulose ether, which may contain suitable anticaking agents; used as a pharmaceutic aid (emulsifying, thickening, and… … Medical dictionary
hydroxypropyl cellulose — see under H … Medical dictionary
Hydroxypropyl methyl cellulose — (E464) (also HPMC) is an emulsifier, thickening and suspending agent, and an alternative to animal gelatin. [ [http://www.ams.usda.gov/nop/NationalList/TAPReviews/HPMethylcellulose.pdf NOSB TAP Review Compiled by OMRI: Hydroxypropyl… … Wikipedia
Cellulose — is an organic compound with the formula chem|(C|6|H|10|O|5|)|n, a polysaccharide consisting of a linear chain of several hundred to over ten thousand β(1→4) linked D glucose units.cite book author=Crawford, R. L. title=Lignin biodegradation and… … Wikipedia
Methyl cellulose — Other names Cellulose, methyl ether; methylated cellulose; methylcellulose; E461 … Wikipedia
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