- P53 p63 p73 family
It consists of:
They are sometimes considered part of a "p53 family".
Evolution of the p53 family
P53, p63, and p73 have similar features in their gene structures and functions but have also diverged evolutionarily. The p53 family evolved from a p63/p73 ancestor gene in invertebrates.  P53 diverged from p63/p73 with a gene duplication in the cartilaginous fish.  P63 and p73 differentiated from each other in bony fish. . These genes developed different functions and structures throughout their evolutionary divergence (TP73L, p73, p53) .
- ^ Levrero M, De Laurenzi V, Costanzo A, Gong J, Wang JY, Melino G (May 2000). "The p53/p63/p73 family of transcription factors: overlapping and distinct functions". J. Cell. Sci. 113 ( Pt 10): 1661–70. PMID 10769197. http://jcs.biologists.org/cgi/pmidlookup?view=long&pmid=10769197.
- ^ Caleb Ellicott Finch (2007). The biology of human longevity: inflammation, nutrition, and aging in the evolution of lifespans. Academic Press. pp. 350–. ISBN 9780123736574. http://books.google.com/books?id=4rGOLEOC4mEC&pg=PA350. Retrieved 23 December 2010.
- ^ Chen S, Moroi Y, Urabe K, et al. (July 2008). "Differential expression of two new members of the p53 family, p63 and p73, in extramammary Paget's disease". Clin. Exp. Dermatol. 33 (5): 634–40. doi:10.1111/j.1365-2230.2008.02851.x. PMID 18627398.
- ^ a b c Levine, A. J., V. A. Belyi, P. Ak, E. Markert, H. J. Wang, W. W. Hu, and A. Puzio-Kuter. (2010). "The origins and evolution of the p53 family of genes". Cold Spring Harbor Perspectives in Biology 2.
Neoplasm: Tumor suppressor genes/proteins and Oncogenes/Proto-oncogenes Ligand ReceptorTSP: CDH1TSP: PTCH1TSP: TGF beta receptor 2 Intracellular signaling P+PsONCO: Beta-catenin · TSP: APCHippo signaling pathwayOther/unknown NucleusTSP: VHL · ONCO: CBL - MDM2 Mitochondria Other/ungrouped
tumr, epon, para
Cell cycle proteins Cyclin CDK CDK inhibitor P53 p63 p73 family Phases and
checkpointsOther cellular phases
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