Basopenia

Basopenia

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Basopenia (or basocytopenia) is a form of agranulocytosis associated with a deficiency of basophils.cite web |url=http://cancerweb.ncl.ac.uk/cgi-bin/omd?basophilic+leukopenia |title=Definition: basophilic leukopenia from Online Medical Dictionary |format= |work= |accessdate=]

One cause is urticaria.cite journal |author=Lourenço FD, Azor MH, Santos JC, "et al" |title=Activated status of basophils in chronic urticaria leads to interleukin-3 hyper-responsiveness and enhancement of histamine release induced by anti-IgE stimulus |journal=Br. J. Dermatol. |volume=158 |issue=5 |pages=979–86 |year=2008 |month=May |pmid=18341658 |doi=10.1111/j.1365-2133.2008.08499.x |url=http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=0007-0963&date=2008&volume=158&issue=5&spage=979] cite journal |author=Grattan CE, Dawn G, Gibbs S, Francis DM |title=Blood basophil numbers in chronic ordinary urticaria and healthy controls: diurnal variation, influence of loratadine and prednisolone and relationship to disease activity |journal=Clin. Exp. Allergy |volume=33 |issue=3 |pages=337–41 |year=2003 |month=March |pmid=12614448 |doi= |url=http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=0954-7894&date=2003&volume=33&issue=3&spage=337] cite journal |author=Grattan CE, Walpole D, Francis DM, "et al" |title=Flow cytometric analysis of basophil numbers in chronic urticaria: basopenia is related to serum histamine releasing activity |journal=Clin. Exp. Allergy |volume=27 |issue=12 |pages=1417–24 |year=1997 |month=December |pmid=9433937 |doi= |url=]

It has been proposed as an indicator of ovulation.cite journal |author=Soni R, Bose S, Gada D, Potnis V |title=Basopenia as an indicator of ovulation (a short term clinical study) |journal=Indian J. Physiol. Pharmacol. |volume=40 |issue=4 |pages=385–8 |year=1996 |month=October |pmid=9055113 |doi= |url=]

It is difficult to detect without flow cytometry, because normal levels are so low.cite web |url=http://www.clt.astate.edu/wwilliam/unit_03.htm |title=CLS_3223_Unit 03_WBC |format= |work= |accessdate=]

It can be defined as less than 0.01 x 10^9 / L.cite web |url=http://www.med-ed.virginia.edu/courses/path/innes/wcd/leukopenia.cfm |title=Pathology |format= |work= |accessdate=]

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