Dicobalt edetate

Dicobalt edetate
Other names Kelocyanor
Identifiers
CAS number	36499-65-7 Y
PubChem	71942
ChemSpider	64951 Y
Jmol-3D images	Image 1 Image 2
SMILES C(CN(CC(=O)[O-])CC(=O)[O-])N(CC(=O)[O-])CC(=O)[O-].[Co+2].[Co+2] [Co+2].[Co+2].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O
InChI InChI=1S/C10H16N2O8.2Co/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;/q;2*+2/p-4 Y Key: TWAWHTJKASJPEK-UHFFFAOYSA-J Y InChI=1/C10H16N2O8.2Co/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;/q;2*+2/p-4 Key: TWAWHTJKASJPEK-XBHQNQODAQ
Properties
Molecular formula	C10H12Co2N2O8.6H2O
Molar mass	406.08 g/mol 514.18 g/mol (hexahydrate)
N edetate (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Dicobalt edetate is the coordination compound with the approximate formula Co₂(EDTA)(H₂O)₆.

Solutions of this solid have been used in Europe as an antidote to cyanide poisoning.^[1]

It is a derivative of the (non-natural) amino acid ethylenediaminetetraacetate.

Structure

The compound is polymeric in the crystalline form. Half of the Co²⁺ ions are bound to the EDTA²⁻ and the other Co²⁺ ions are bound to four water ligands as well as carboxylate ligands on the [Co(EDTA)]²⁻ entity.^[2] In aqueous solution, depolymerization occurs to give [Co(EDTA)]²⁻ and [Co(H₂O)₆]²⁺ ions, each of which is kinetically labile and has a high affinity for cyanide. Oxidants would convert the [Co(EDTA)]²⁻ into [Co(EDTA)]⁻, which would be unreactive toward cyanide because this complex would be "inert."^[3]

References

1. ^ Pickering WG (December 1985). "Cyanide toxicity and the hazards of dicobalt edetate". Br Med J (Clin Res Ed) 291 (6509): 1644. doi:10.1136/bmj.291.6509.1644-a. PMC 1418389. PMID 2866807. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1418389. 
2. ^ E. F. K. Mccandlish, T. K. Michael; Rose, N. J.; Neal, J. A.; Lingafelter, E. C.; Rose, N. J. (1978). "Comparison of the Structures and Aqueous Solutions of [(O-Phenylenediaminetetraacetato(2-)]Cobalt(II) and [Ethylenediaminetetraacetato(2-)]Cobalt(II)". Inorg. Chem. 17 (6): 1383–94. doi:10.1021/ic50184a001. 
3. ^ Dwyer, F. P.; Garvan, F. L.; Kirschner, Stanley (1960). "Resolution of the Ethylenediaminetetracetatocobaltate(III) Ion". Inorg. Synth.. Inorganic Syntheses 4: 192–4. doi:10.1002/9780470132371.ch61. ISBN 9780470132371. 

This pharmacology-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Cobalt compounds Pharmacology stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем решить контрольную работу United States presidential election in California, 1860 Charles Joseph Dolan Look at other dictionaries: edetate — USAN approved contraction for ethylenediaminetetraacetate, the anion of ethylenediaminetetraacetic acid; various edetates are used as chelating agents to carry cations in ( e.g., ferric sodium e. as an iron ion carrier) or out ( e.g., sodium e.… …   Medical dictionary edetate — n. a salt of ethylenediaminetetraacetic acid (EDTA), which is used as a chelating agent in the treatment of poisoning. Dicobalt edetate is an antidote to cyanide, administered by intravenous injection as soon as possible after poisoning. Sodium… …   The new mediacal dictionary Эдитат (Edetate) — соль этилендиаминтетрауксусной кислоты (ethylenediaminetetraacetic acid (EDTA)); применяется в качестве хелатирующего агента при лечении различных отравлений. Эдитат дикобальта (dicobalt edetate) является антидотом цианидов; в случае отравлений… …   Медицинские термины Cyanide poisoning — Classification and external resources Cyanide ion ICD 10 T …   Wikipedia Intoxication au cyanure — Classification et ressources externes Cyanide ion CIM 10 …   Wikipédia en Français Paramedics in the United Kingdom — In the United Kingdom the term paramedic is protected by law and only applies to ambulance practitioners who are able to achieve and maintain the strict standards established by a statutory body. The Health Professions Council (HPC) requires… …   Wikipedia cyanide — 1. The radical –CN or ion (CN)−. The ion is extremely poisonous, forming hydrocyanic acid in water, it has the odor of almond oil; inhibits respiratory proteins (cytochromes) at the cellular level. 2. A salt of HCN or a cyano containing …   Medical dictionary cyanide — n. any of the notoriously poisonous salts of hydrocyanic acid. Cyanides combine with and render inactive the enzymes of the tissues responsible for cellular respiration, and therefore they kill extremely quickly; unconsciousness is followed by… …   The new mediacal dictionary 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”