- Stryker's reagent
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CASNo=33636-93-0
PubChem=12181933
SMILES=C1=CC=C(C=C1)P(C2=CC=CC=C2)C3=CC=CC=C3.C1=CC=C(C=C1)P(C2=CC=CC=C2)C3=CC=CC=C3.C1=CC=C(C=C1)P(C2=CC=CC=C2)C3=CC=CC=C3.C1=CC=C(C=C1)P(C2=CC=CC=C2)C3=CC=CC=C3.C1=CC=C(C=C1)P(C2=CC=CC=C2)C3=CC=CC=C3.C1=CC=C(C=C1)P(C2=CC=CC=C2)C3=CC=CC=C3. [CuH] . [CuH] . [CuH] . [CuH] . [CuH] . [CuH]
Section2=Chembox Properties
Formula=C108H96Cu6P6
MolarMass=1961.036406
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Autoignition=Stryker's reagent ( [(PPh3)CuH] 6 [cite journal | title = Selective Hydride-mediated conjugate reduction of α,β-unsaturated Carbonyl Compounds Using [(Ph3P)CuH] 6 | author = Mahoney, W.S.; Brestensky, D.M.; Stryker, J.M. | journal =
J. Am. Chem. Soc. | year = 1988 | volume = 110 | pages = 291-293 | doi = 10.1021/ja00209a048] , also known as the Osborn complex, is a hexameric copper hydride ligated withtriphenylphosphine . [cite journal | title = Preparation and Crystallographic Characterization of a Hexameric Triphenylphosphinecopper Hydride Cluster | author = Bezman, S. A.; Churchill, M. R.; Osborn, J. A.; Wormald, J. | journal =J. Am. Chem. Soc. | year = 1971 | volume =93 | pages = 2063-2065 | doi = 10.1021/ja00737a045] It is a brick red crystalline solid that is very sensitive to air. Stryker's reagent is a mild hydride source and is used in homogeneous catalysis of conjugate reduction reactions of various compounds (enones, enoates, etc).Preparation and Stability
Stryker's reagent is prepared from copper(I) "tert"-butoxide, generated in situ from
copper(I) chloride and sodium "tert"-butoxide, and pressurizedhydrogen . It can be directly prepared from copper(II) salts as well. [cite journal | title = Direct synthesis of Stryker's reagent from Cu(II) salt | author = Lee, D. W.; Yun, J. | journal =Tetrahedron Lett. | year = 2005 | volume = 46 | pages = 2037-2039 | doi = 10.1016/j.tetlet.2005.01.127] If stored under an inert atmosphere (e.g. argon, nitrogen) it has indefinite shelf life. Brief exposure to the oxygen does not destroy its activity significantly, although solvents used with Stryker's reagent should be rigorously degassed. [e-EROS Encyclopedia of Reagents for Organic Synthesis http://www.mrw.interscience.wiley.com/eros/articles/rh011m/sect0-fs.html ]Modifications to Stryker's reagent
Ligand modified versions of Stryker's reagent have been reported. These modifications claim to be more reactive and/or more stable in the atmosphere.
References
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