SERPINA9

protein
name=serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9
caption=


width=
HGNCid=15995
Symbol=SERPINA9
AltSymbols= Centerin, SERPINA11b, GCET1
EntrezGene=327657
OMIM=
RefSeq=NM_175739
UniProt= Q86WD7
PDB=
ECnumber=
Chromosome=14
Arm=q
Band=32.1
LocusSupplementaryData=

SERPINA9 also known as centerin or GCET1 is a human gene.cite web | title = Entrez Gene: SERPINA9 | url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=327657| accessdate = ] The protein encoded by this gene is a member of the serpin family of serine protease inhibitors.

The expression of SERPINA9 is restricted to germinal center B cells and lymphoid malignancies. SERPINA9 is likely to function in vivo in the germinal center as an efficient inhibitor of trypsin-like proteases.cite journal | author = Paterson MA, Horvath AJ, Pike RN, Coughlin PB | title = Molecular characterization of centerin, a germinal centre cell serpin | journal = Biochem. J. | volume = 405 | issue = 3 | pages = 489–94 | year = 2007 | month = August | pmid = 17447896 | pmc = 2267310 | doi = 10.1042/BJ20070174 | url = | issn = ] cite journal | author = Montes-Moreno S, Roncador G, Maestre L, Martínez N, Sanchez-Verde L, Camacho FI, Cannata J, Martinez-Torrecuadrada JL, Shen Y, Chan WC, Piris MA | title = Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomas | journal = Blood | volume = 111 | issue = 1 | pages = 351–8 | year = 2008 | month = January | pmid = 17898315 | doi = 10.1182/blood-2007-06-094151 | url = | issn = ] cite journal | author = Paterson MA, Hosking PS, Coughlin PB | title = Expression of the serpin centerin defines a germinal center phenotype in B-cell lymphomas | journal = Am. J. Clin. Pathol. | volume = 130 | issue = 1 | pages = 117–26 | year = 2008 | month = July | pmid = 18550480 | doi = 10.1309/9QKE68QU7B825A3U | url = | issn = ]

References

External links

*