HLA-B75

HLA-B75


Diseases

HLA-B*1502 is associated with Carbamazepine and phenytoin induced Stevens-Johnson syndrome in Chinese and Thai.cite journal |author=Locharernkul C, Loplumlert J, Limotai C, "et al" |title=Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population |journal=Epilepsia |volume= |issue= |pages= |year=2008 |month=July |pmid=18637831 |doi=10.1111/j.1528-1167.2008.01719.x |url=] cite journal |author=Man CB, Kwan P, Baum L, "et al" |title=Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese |journal=Epilepsia |volume=48 |issue=5 |pages=1015–8 |year=2007 |month=May |pmid=17509004 |doi=10.1111/j.1528-1167.2007.01022.x |url=] One study showed a 100% association between B*1502 and the drug induced skin disorder in Chinese. In Europe the B*1502 positive patients are only found in this syndrome of persons of East Asian descent, however B58 confers susceptibility to both groups but to a lessor degree and is sensitive to allopurinol.

References


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