- Biomedical research
Biomedical research (or experimental medicine), in general simply known as medical research, is the
basic researchor applied researchconducted to aid the body of knowledge in the field of medicine. Medical research can be divided into two general categories: the evaluation of new treatments for both safety and efficacy in what are termed clinical trials, and all other research that contributes to the development of new treatments. The latter is termed preclinical research if its goal is specifically to elaborate knowledge for the development of new therapeutic strategies.
The increased longevity of humans over the past century can be significantly attributed to advances resulting from medical research. Among the major benefits have been
vaccines for measlesand polio, insulintreatment for diabetes, classes of antibiotics for treating a host of maladies, medication for high blood pressure, improved treatments for AIDS, statins and other treatments for atherosclerosis, new surgical techniques such as microsurgery, and increasingly successful treatments for cancer. New, beneficial tests and treatments are expected as a result of the human genome project. Many challenges remain, however, including the appearance of antibiotic resistanceand the obesityepidemic.
Most of the research in the field is pursued by
biomedical scientists in cooperation with molecular biologists.
Preclinical research is research in
basic science, which precedes the clinical trials, and is almost purely based on theory and animal experiments.
New treatments come about as a result of other, earlier discoveries — often unconnected to each other, and in various fields. Sometimes the research is done for non-medical purposes, and only by accident contributes to the field of medicine (for example, the discovery of
penicillin). Clinicians use these discoveries to create a treatment regimen, which is then tested in clinical trials.
A clinical trial is a comparison test of a
medicationor other medical treatment, versus a placebo, other medications and devices, or the standard medical treatment for a patient's condition. Clinical trials vary greatly in size: from a single researcher in one hospital or clinic to an international multicenter trialwith several hundred participating researchers on several continents. The number of patients tested can range from as few as a dozen to several thousands.
Research fundingin many countries comes from research bodies which distribute money for equipment and salaries. In the UK, funding bodies such as the Medical Research Council and the Wellcome Trustderive their assets from UK tax payers, and distribute this to institutions in a competitive manner.
In the United States, the most recent data from 2003cite journal | author = Moses H, Dorsey E, Matheson D, Thier S | title = Financial anatomy of biomedical research. | journal = JAMA | volume = 294 | issue = 11 | pages = 1333–42 | year = 2005 | pmid = 16174691 | doi = 10.1001/jama.294.11.1333] suggest that about 94 billion dollars were provided for biomedical research in the United States. The
National Institutes of Healthand pharmaceutical companies collectively contribute 26.4 billion dollars and 27.0 billion dollars, respectively, which constitute 28% and 29% of the total, respectively. Other significant contributors include biotechnologycompanies (17.9 billion dollars, 19% of total), medical device companies (9.2 billion dollars, 10% of total), other federal sources, and state and local governments. Foundations and charities, led by the Bill and Melinda Gates Foundation, contributed about 3% of the funding.
Regulations and guidelines
Medical research is highly regulated. National regulatory authorities oversee and monitor medical research, such as for the development of new drugs. In the
USAthe Food and Drug Administrationoversees new drug development, in Europe the European Medicines Agency(see also EudraLex), and in Japanthe Ministry of Health, Labour and Welfare (Japan). The World Medical Associationdevelops the ethical standards for the medical profession, involved in medical research. The International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use(ICH) works on the creation of rules and guidelines for the development of new medication, such as the guidelines for Good Clinical Practice (GCP).
Fields of research
Fields of biomedical research include:
Medical research scientist
Title 21 of the Code of Federal Regulations(USA)
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*cite journal | author = Beyleveld D & Pattinson S D | title = Medical Research into Emergency Treatment: Regulatory Tensions in England and Wales. | journal = Web JCLI | volume = 5 | year = 2006 [http://webjcli.ncl.ac.uk/2006/issue5/beyleveld5.html full text]
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