Alpha-2 blocker

Alpha-2 blocker

Although alpha blocker generally refers to α1-blockers, there are also α2-blockers, which are antagonists to the α2 adrenergic receptor. They are mainly used in research, finding little clinical application.

Examples

Examples include atipamezole,cite journal |author=Haapalinna A, Leino T, Heinonen E |title=The alpha 2-adrenoceptor antagonist atipamezole potentiates anti-Parkinsonian effects and can reduce the adverse cardiovascular effects of dopaminergic drugs in rats |journal=Naunyn Schmiedebergs Arch. Pharmacol. |volume=368 |issue=5 |pages=342–51 |year=2003 |month=November |pmid=14566451 |doi=10.1007/s00210-003-0827-z] efaroxan, idazoxan,cite journal |author=Chopin P, Colpaert FC, Marien M |title=Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway |journal=J. Pharmacol. Exp. Ther. |volume=288 |issue=2 |pages=798–804 |year=1999 |month=February |pmid=9918591 |doi= |url=http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=9918591] yohimbine, benzylpiperazine, and rauwolscine.

References


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