ROD-188

ROD-188

drugbox
IUPAC_name = (5R)-5- [(1R)-2-(4-methylphenyl)sulfonyl-3,4-dihydro-1H-isoquinolin-1-yl] oxolan-2-one


width = 200
CAS_number =
ATC_prefix =
ATC_suffix =
PubChem = 9842377
DrugBank =
C = 20 | H = 21 | N = 1 | O = 4 | S = 1
molecular_weight = 371.449 g/mol
smiles = c3cc(C)ccc3S(=O)(=O)N2CCc1ccccc1C2C(CC4)OC4=O
bioavailability =
protein_bound =
metabolism =
elimination_half-life =
excretion =
pregnancy_AU =
pregnancy_US =
pregnancy_category=
legal_AU =
legal_CA =
legal_UK =
legal_US =
legal_status = Legal
routes_of_administration =

ROD-188 is a sedative drug structurally derived from the GABAA antagonist bicuculline. Unlike bicuculline, ROD-188 acts as an agonist at GABAA receptors, being a positive allosteric modulator acting at a novel binding site distinct from those of benzodiazepines, barbiturates or muscimol, with its strongest effect produced at the α6β2γ2 subtype of the GABAA receptor. [Thomet U, Baur R, Razet R, Dodd RH, Furtmüller R, Sieghart W, Sigel E. A novel positive allosteric modulator of the GABA(A) receptor: the action of (+)-ROD188. "British Journal of Pharmacology". 2000 Oct;131(4):843-50. PMID 11030736] ROD-188 is one of a number of related compounds acting at this novel modulatory site, some of which also act at benzodiazepine receptors. [Sigel E, Baur R, Furtmueller R, Razet R, Dodd RH, Sieghart W. Differential cross talk of ROD compounds with the benzodiazepine binding site. "Molecular Pharmacology". 2001 Jun;59(6):1470-7. PMID 11353808]

References


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

  • Rod Carew — Saltar a navegación, búsqueda Rodney Cline Carew (Gatún, Panamá, 1 de octubre de 1945) fue un jugador de las Grandes Ligas de Béisbol con los equipos de Minnesota Twins y California Angels en los años 1970 y 1980. Es probablemente el único… …   Wikipedia Español

  • Rod Smart — Infobox NFLactive name=Rod Smart |width=200 caption= currentteam=Team Tennessee currentnumber= currentpositionplain=Running back, Kick returner birthdate=Birth date and age|1977|1|9 birthplace=Lakeland, Florida country=USA heightft=5 heightin=11… …   Wikipedia

  • Rod's Pot — Infobox Cave name = Rod s Pot location = Burrington Combe depth = 45 metres cite web | url= http://www.yucpc.org.uk/caves/details.asp?id=120 | work= York University Cave Pothole Club | title= Rod s Pot Cave Info | accessdate= 2007 10 15] length …   Wikipedia

  • Rod Lester-Smith — Infobox afl player | firstname = Rod lastname = Lester Smith birthdate = 18 July 1959 birthplace = originalteam = East Fremantle heightweight = 188 cm / 89 kg dead = deathdate = deathplace = debutdate = 1984 debutteam = Hawthorn debutopponent =… …   Wikipedia

  • X-ray crystal truncation rod — scattering is a powerful method in surface science, based on analysis of X ray diffraction patterns from a crystalline surface. For an infinite crystal, the diffracted pattern is concentrated in delta function like Bragg peaks. Presence of… …   Wikipedia

  • Propofol — Systematic (IUPAC) name 2,6 diisopropylphenol …   Wikipedia

  • Trional — Systematic (IUPAC) name 2,2 bis(ethylsulfonyl)butane Clinical data Pregnancy cat.  ? …   Wikipedia

  • Metomidate — Systematic (IUPAC) name methyl 1 (1 phenylethyl) 1H imidazole 5 carboxylate Clinical data Pregnancy cat.  ? …   Wikipedia

  • Benzodiazepine — Benzodiazepines …   Wikipedia

  • Ethanol — For other uses, see Ethanol (disambiguation). Grain alcohol redirects here. It is not to be confused with Neutral grain spirit. Ethanol …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”