SCN10A


SCN10A
sodium channel, voltage-gated, type X, alpha subunit
Identifiers
Symbols SCN10A; PN3; SNS; hPN3
External IDs OMIM604427 MGI108029 HomoloGene21300 IUPHAR: Nav1.8 GeneCards: SCN10A Gene
Orthologs
Species Human Mouse
Entrez 6336 20264
Ensembl ENSG00000185313 ENSMUSG00000034533
UniProt Q9Y5Y9 Q6QIY3
RefSeq (mRNA) NM_006514 NM_009134
RefSeq (protein) NP_006505 NP_033160
Location (UCSC) Chr 3:
38.71 – 38.81 Mb
Chr 9:
119.52 – 119.6 Mb
PubMed search [1] [2]
This box: view · protein which in humans is encoded by the SCN10A gene.[1]

Nav1.8 is a sodium channel subunit.[2][3][4]

Function

This subtype of voltage-gated sodium channel is expressed in nociceptors and has been proposed as a target for the development of new analgesics.[5]

References

  1. ^ "Entrez Gene: sodium channel". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6336. 
  2. ^ Rabert DK, Koch BD, Ilnicka M, Obernolte RA, Naylor SL, Herman RC, Eglen RM, Hunter JC, Sangameswaran L (November 1998). "A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A". Pain 78 (2): 107–14. doi:10.1016/S0304-3959(98)00120-1. PMID 9839820. 
  3. ^ Plummer NW, Meisler MH (April 1999). "Evolution and diversity of mammalian sodium channel genes". Genomics 57 (2): 323–31. doi:10.1006/geno.1998.5735. PMID 10198179. 
  4. ^ Catterall WA, Goldin AL, Waxman SG (December 2005). "International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels". Pharmacol. Rev. 57 (4): 397–409. doi:10.1124/pr.57.4.4. PMID 16382098. 
  5. ^ Cummins TR, Sheets PL, Waxman SG (October 2007). "Voltage-gated sodium channel blockers for the treatment of chronic pain". Pain 131 (3): 243–57. PMID 19442207. 

Further reading

see also disorders
B memb: cead, trns (1A, 1C, 1F, 2A, 3A1, 3A2-3, 3D), othr

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