Mebendazole Systematic (IUPAC) name methyl (5-benzoyl-1H-benzimidazol-2-yl)carbamate Clinical data AHFS/Drugs.com MedlinePlus Pregnancy cat. C Legal status ? Routes Oral Pharmacokinetic data Bioavailability ~2% Metabolism Hepatic Half-life 2.5 to 5.5 hours Identifiers CAS number ATC code P02 QP52 PubChem DrugBank ChemSpider UNII KEGG ChEBI ChEMBL Chemical data Formula C16H13N3O3 Mol. mass 295.293 g/mol SMILES & Physical data Melt. point 288.5 °C (551 °F) (what is this?)
Mebendazole or MBZ is a benzimidazole drug developed by Janssen Pharmaceutica and marketed as Vermox, Ovex, Antiox, and Pripsen. It is used to treat infestations by worms including pinworms, roundworms, tapeworms, hookworms, and whipworms.
The drug is a highly effective broad spectrum anthelmintic indicated for the treatment of nematode infestations, including round worm, whip worm, thread worm, and hook worm. It is poorly absorbed and has no systemic effects.
Mebendazole is thought to work by selectively inhibiting the synthesis of microtubules in parasitic worms, and by destroying extant cytoplasmic microtubes in their intestinal cells: thereby blocking the uptake of glucose and other nutrients, resulting in the gradual immobilization and eventual death of the helminths.
Oral dosage for treatment of pinworms is 100 mg taken once. This regimen is repeated two weeks later if the infestation has not cleared up. Oral dosage for treatment of whipworm, common roundworm and hookworm is one 100-mg tablet morning and evening for 3 consecutive days. Dosage is the same for both adults and children.
Mebendazole is relatively free of toxic side effects or adverse reactions, although patients may complain of transient abdominal pain, diarrhea, slight headache, fever, dizziness, exanthema, urticaria and angioedema.
Mebendazole is contraindicated in pregnant women because it has been shown to be embryotoxic and teratogenic in experimental animals.
- ^ "Mebendazole". Drugs.com. http://www.drugs.com/pro/mebendazole.html. Retrieved 2011-10-29.
- ^ "Drug Interactions". Medicine chest. http://www.medicinechestonline.co.uk/static/professional2/drug_interactions.htm. Retrieved 2008-05-06.
- ^ Luder, P. J.; Siffert, B.; Witassek, F.; Meister, F.; Bircher, J. (1986). "Treatment of hydatid disease with high oral doses of mebendazole. Long-term follow-up of plasma mebendazole levels and drug interactions". European journal of clinical pharmacology 31 (4): 443–448. PMID 3816925.
- ^ Chen, K. T.; Twu, S. J.; Chang, H. J.; Lin, R. S. (2003). "Outbreak of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Associated with Mebendazole and Metronidazole Use Among Filipino Laborers in Taiwan". American journal of public health 93 (3): 489–492. PMC 1447769. PMID 12604501. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1447769.
- Vermox (UK manufacturer's website)
Antiparasitics – Anthelmintics (P02) Antiplatyhelmintic agentsAntitrematodals
helm, arth (lice), zoon
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