Acute coronary syndrome

Infobox_Disease
Name = PAGENAME


Caption =
DiseasesDB =
ICD10 =
ICD9 =
ICDO =
OMIM =
MedlinePlus =
eMedicineSubj = emerg
eMedicineTopic = 31
MeshID = D054058
An acute coronary syndrome (ACS) is a set of signs and symptoms (syndrome) related to the heart. ACS is compatible with a diagnosis of acute myocardial ischemia,cite web |url=http://www.americanheart.org/presenter.jhtml?identifier=3010002 |title=Acute Coronary Syndrome |format= |work= |accessdate=] but it is not pathognomonic.

The subtypes of acute coronary syndrome include unstable angina (UA, not associated with heart muscle damage), and two forms of myocardial infarction (heart attack), in which heart muscle is damaged. These types are named according to the appearance of the electrocardiogram (ECG/EKG) as "non-ST segment elevation myocardial infarction" (NSTEMI) and "ST segment elevation myocardial infarction" (STEMI).cite journal |author=Grech ED, Ramsdale DR |title=Acute coronary syndrome: unstable angina and non-ST segment elevation myocardial infarction |journal=BMJ |volume=326 |issue=7401 |pages=1259–61 |year=2003 |month=June |pmid=12791748 |pmc=1126130 |doi=10.1136/bmj.326.7401.1259 |url=http://bmj.com/cgi/pmidlookup?view=long&pmid=12791748] There can be some variation as to which forms of MI are classified under acute coronary syndrome.cite web |url=http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/nine/14170699.htm |title=Dorlands Medical Dictionary:acute coronary syndrome |format= |work= |accessdate=]

ACS should be distinguished from stable angina, which develops during exertion and resolves at rest. In contrast with stable angina, unstable angina occurs suddenly, often at rest or with minimal exertion, or at lesser degrees of exertion than the individual's previous angina ("crescendo angina"). New onset angina is also considered unstable angina, since it suggests a new problem in a coronary artery.

Though ACS is usually associated with coronary thrombosis, it can also be associated with cocaine use. [cite journal |author=Achar SA, Kundu S, Norcross WA |title=Diagnosis of acute coronary syndrome |journal=Am Fam Physician |volume=72 |issue=1 |pages=119–26 |year=2005 |pmid=16035692 |doi= |url=http://www.aafp.org/afp/20050701/119.html]

igns and symptoms

The cardinal sign of decreased blood flow to the heart is chest pain experienced as tightness around the chest and radiating to the left arm and the left angle of the jaw. This may be associated with diaphoresis (sweating), nausea and vomiting, as well as shortness of breath. In many cases, the sensation is "atypical", with pain experienced in different ways or even being completely absent (which is more likely in female patients and those with diabetes). Some may report palpitations, anxiety or a sense of impending doom and a feeling of being acutely ill.

Diagnosis

Electrocardiogram

In the setting of acute chest pain, the electrocardiogram is the investigation that most reliably distinguishes between various causes. [cite journal |author=Chun AA, McGee SR |title=Bedside diagnosis of coronary artery disease: a systematic review |journal=Am. J. Med. |volume=117 |issue=5 |pages=334–43 |year=2004 |pmid=15336583 |doi=10.1016/j.amjmed.2004.03.021] If this indicates acute heart damage (elevation in the "ST segment", new left bundle branch block), treatment for a heart attack in the form of angioplasty or thrombolysis is indicated immediately (see below). In the absence of such changes, it is not possible to immediately distinguish between unstable angina and NSTEMI.

Imaging and blood tests

As it is only one of the many potential causes of chest pain, the patient usually has a number of tests in the emergency department, such as a chest X-ray, blood tests (including myocardial markers such as troponin I or T, and a D-dimer if a pulmonary embolism is suspected), and telemetry (monitoring of the heart rhythm).

Prediction scores

The ACI-TIPI score can be used to aid diagnosis; using 7 variables from the admission record, this score predicts crudely which patients are likely to have myocardial ischemia.cite journal |author=Selker HP, Griffith JL, D'Agostino RB |title=A tool for judging coronary care unit admission appropriateness, valid for both real-time and retrospective use. A time-insensitive predictive instrument (TIPI) for acute cardiac ischemia: a multicenter study |journal=Medical care |volume=29 |issue=7 |pages=610–27 |year=1991 |pmid=2072767 |doi=]

Prognosis

TIMI score

The TIMI risk score can identify high risk patientscite journal |author=Antman EM, Cohen M, Bernink PJ, "et al" |title=The TIMI risk score for unstable angina/non-ST elevation MI: A method for prognostication and therapeutic decision making |journal=JAMA |volume=284 |issue=7 |pages=835–42 |year=2000 |pmid=10938172 |doi=] and has been independently validated.cite journal |author=Pollack CV, Sites FD, Shofer FS, Sease KL, Hollander JE |title=Application of the TIMI risk score for unstable angina and non-ST elevation acute coronary syndrome to an unselected emergency department chest pain population |journal=Academic emergency medicine : official journal of the Society for Academic Emergency Medicine |volume=13 |issue=1 |pages=13–8 |year=2006 |pmid=16365321 |doi=10.1197/j.aem.2005.06.031] cite journal |author=Chase M, Robey JL, Zogby KE, Sease KL, Shofer FS, Hollander JE |title=Prospective validation of the Thrombolysis in Myocardial Infarction Risk Score in the emergency department chest pain population |journal=Annals of emergency medicine |volume=48 |issue=3 |pages=252–9 |year=2006 |pmid=16934646 |doi=10.1016/j.annemergmed.2006.01.032]

Biomarkers for diagnosis

The aim of diagnostic markers is to identify patients with ACS even when there is no evidence of myocyte necrosis.
*Ischemia-Modified Albumin (IMA) - In cases of Ischemia - Albumin undergoes a conformational change and loses its ability to bind transitional metals (copper or cobalt). IMA can be used to assess the proportion of modified albumin in ischemia. Its use is limited to ruling out ischemia rather than a diagnostic test for the occurrence of ischemia.
*Myeloperoxidase (MPO) - The levels of circulating MPO, a leukocyte enzyme, elevate early after ACS and can be used as an early marker for the condition.

*Glycogen Phosphorylase Isoenzyme BB-(GPBB) is an early marker of cardiac ischemia and is one of three isoenzyme of Glycogen Phosphorylase.

*Troponin is a late cardiac marker of ACS

Biomarkers for Risk Stratification

The aim of prognostic markers is to reflect different components of pathophysiology of ACS. For example:
*Natriuretic peptide - Both B-type natriuretic peptide (BNP) and N-terminal Pro BNP can be applied to predict the risk of death and heart failure following ACS.
*Monocyte chemo attractive protein (MCP)-1 - has been shown in a number of studies to identify patients with a higher risk of adverse outcomes after ACS.

Treatment

TEMI

If the ECG confirms changes suggestive of myocardial infarction (ST elevations in specific leads, a new left bundle branch block or a true posterior MI pattern), thrombolytics may be administered or primary coronary angioplasty may be performed. In the former, medication is injected that stimulates fibrinolysis, destroying blood clots obstructing the coronary arteries. In the latter, a flexible catheter is passed via the femoral or radial arteries and advanced to the heart to identify blockages in the coronaries. When occlusions are found, they can be intervened upon mechanically with angioplasty and perhaps stent deployment if a lesion, termed the "culprit" lesion, is thought to be causing myocardial damage.

NSTEMI and NSTE-ACS

If the ECG does not show typical changes, the term "non-ST segment elevation ACS" is applied. The patient may still have suffered a "non-ST elevation MI" (NSTEMI). The accepted management of unstable angina and acute coronary syndrome is therefore empirical treatment with aspirin, heparin (usually a low-molecular weight heparin such as enoxaparin) and clopidogrel, with intravenous glyceryl trinitrate and opioids if the pain persists.

A blood test is generally performed for cardiac troponins twelve hours after onset of the pain. If this is positive, coronary angiography is typically performed on an urgent basis, as this is highly predictive of a heart attack in the near-future. If the troponin is negative, a treadmill exercise test or a thallium scintigram may be requested.

Prevention

Acute coronary syndrome often reflects a degree of damage to the coronaries by atherosclerosis. Primary prevention of atherosclerosis is controlling the risk factors: healthy eating, exercise, treatment for hypertension and diabetes, avoiding smoking and controlling cholesterol levels); in patients with significant risk factors, aspirin has been shown to reduce the risk of cardiovascular events. Secondary prevention is discussed in myocardial infarction.

After a ban on smoking in all enclosed public places was introduced in Scotland in March 2006, there was a 17 percent reduction in hospital admissions for acute coronary syndrome. 67% of the decrease occurred in non-smokers. [cite journal| doi=10.1056/NEJMsa0706740| title=Smoke-free Legislation and Hospitalizations for Acute Coronary Syndrome| year=2008| author=Pell JP, Haw S, Cobbe S "et al"| journal=New England Journal of Medicine| volume=359| pages=482]

References