Minimal change disease

Minimal change disease
Minimal Change Disease
Classification and external resources

The three hallmarks of Minimal Change Disease: diffuse loss of podocyte foot processes, vacuolation, and the appearance of microvilli.
ICD-10 N00-N08 with .0 suffix
ICD-9 581.3
DiseasesDB 8230
MedlinePlus 000496
eMedicine med/1483

Minimal Change Disease (also known as Nil Lesions or Nil Disease (lipoid nephrosis)) is a disease of the kidney that causes nephrotic syndrome and usually affects children (peak incidence at 2–3 years of age).[1]



Minimal Change Disease is most common in very young children but can occur in older children and adults. It is by far the most common cause of nephrotic syndrome (NS) in children between the ages of 1 and 7, accounting for the majority (about 90%) of these diagnoses.[2] Among teenagers who develop NS, it is caused by minimal change disease about half the time. It can also occur in adults but accounts for less than 20% of adults diagnosed with NS. Among children less than 10 years of age, boys seem to be more likely to develop minimal change disease than girls.

People with 1 or more autoimmune disorders are at increased risk of developing minimal change disease. Having minimal change disease also increases the chances of developing other autoimmune disorders.


The symptoms are proteinuria (leakage of protein into the urine) and edema (water retention). Nephrotic syndrome (NS) is a general term that refers to the loss of protein in the urine, hypercholesterolemia, and edema. Many conditions are categorized as nephrotic syndromes—minimal change disease is unique, because it is the only one lacking any evidence of pathology on light microscopy (hence the name).

When protein is lost in the urine, the concentration of protein in the blood decreases, allowing water to move into other areas of the body, which leads to swelling known as edema. Edema is commonly observed in the feet and legs, in the belly or abdomen (ascites), and around the eyes, but can occur anywhere, especially in response to gravity. Additionally, because of this extra fluid that stays in the body, people often gain weight and experience fatigue—in many patients, for example, their usual clothes and shoes will no longer fit. Some people notice that their urine becomes more frothy or foamy from the excess protein in the urine, and may find that they urinate less often.


For years pathologists found no changes when viewing specimens under light microscopy; hence the name minimal change disease. With the advent of electron microscopy, the changes now known as the hallmarks for the disease were discovered. These are diffuse loss of visceral epithelial cells (podocyte) foot processes.,[3] vacuolation, and growth of microvilli on the visceral epithelial cells.

The pathology of minimal change disease is unclear and is currently considered idiopathic. The pathology does not appear to involve complement, immunoglobulins, or immune complex deposition. Rather, an altered cell-mediated immunologic response with abnormal secretion of lymphokines by T cells is thought to reduce the production of anions in the glomerular basement membrane, thereby increasing the glomerular permeability to serum albumin[4] through a reduction of electrostatic repulsion.[5] The loss of anionic charges is also thought to favor foot process fusion.[1] The etiological agent is somewhat of a mystery but viruses such as EBV, and food allergies have been implicated. Also, the exact cytokine responsible has yet to be elucidated, with IL-12, IL-18 and IL-13 having been most studied in this regard, yet never conclusively implicated.


Protein tyrosine phosphatase receptor type O - also known as glomerular epithelial protein 1 [GLEPP1] has been shown to be mutated in a number of cases.[6]


Prednisone is prescribed along with a blood pressure medication, typically an ACE inhibitor such as lisinopril. Some nephrologists will start out with the ACE inhibitor first in an attempt to reduce the blood pressure's force which pushes the protein through the cell wall in order to lower the proteinuria. In some cases a corticosteroid may not be necessary if the case of minimal change disease is mild enough to be treated just with the ACE Inhibitor. Often the liver is overactive with minimal change disease in an attempt to replace lost protein and over produces cholesterol. Therefore a statin drug is often prescribed for the duration of the treatment. When the urine is clear of protein, the drugs can be discontinued. 50% of patients will relapse and need further treatment with immunosuppressants such as cyclosporine and tacrolimus.

Minimal change disease usually responds well to initial treatment and over 90% of patients will respond to oral steroids within 6–8 weeks, with most of these having a complete remission.[7] Symptoms of nephrotic syndrome (NS) typically going away, but this can take from 2 weeks to many months.[7] Younger children, who are more likely to develop minimal change disease, usually respond faster than adults. In 2 out of 3 children with minimal change disease, however, the symptoms of NS can reoccur, called a relapse, particularly after an infection or an allergic reaction. This is typical, and usually requires additional treatment. Many children experience 3 to 4 relapses before the disease starts to go away. Some children require longer term therapy to keep MCD under control. It appears that the more time one goes without a relapse, the better the chances are that a relapse will not occur. In most children with minimal change disease, particularly among those who respond typically, there is minimal to no permanent damage observed in their kidneys.

With steroid treatment, the symptoms of nephrotic syndrome (NS) will go away, called remission, in the majority of children with minimal change disease. This typically occurs faster, over 2 to 8 weeks, in younger children, but can take up to 3 or 4 months in adults. Typically the dose of steroids will initially be fairly high, lasting 1or 2 months. At some point after the urine protein levels have become normal again, the dose of steroids might be switched to an every-other-day schedule, then very slowly reduced over the course of several months. It is very important to taper, or gradually reduce, the dose of steroids. The body does not respond well to a sudden discontinuation of steroids, and this might also trigger a relapse, or return, of NS symptoms. Giving steroids initially for a longer period of time is thought to reduce the likelihood of relapse. The majority of children with minimal change disease will respond to this treatment.

Even among those who respond well to steroids initially, it is common to observe periods of relapse (return of NS symptoms). Because of the potential for relapse, the physician may prescribe and teach the patient how to use a tool to have you check urine protein levels at home. Two out of 3 children who initially responded to steroids will experience this at least once. Typically the steroids will be restarted when this occurs, although the total duration of steroid treatment is usually shorter during relapses than it is during the initial treatment of the disease.

There are several immunosuppressive medications that can be added to steroids when the effect is not sufficient or replace them in case of intolerance or specific contraindications.

Other notes

80% of those who get minimal change disease have a recurrence.

Some authors have noted that other conditions associated with T-cell abnormalities, such as Hodgkin's disease and T-cell lymphoma, are sometimes associated with minimal change disease.

It should also be noted that minimal change disease is being seen with increasing frequency in adults over the age of 80.


  1. ^ a b Kumar V, Fausto N, Abbas A (editors) (2003). Robbins & Cotran Pathologic Basis of Disease (7th ed.). Saunders. pp. 981–2. ISBN 978-0-721-60187-8. 
  2. ^ Cameron, J S (1987-09). "The nephrotic syndrome and its complications". American Journal of Kidney Diseases 10 (3): 157–171. ISSN 0272-6386. PMID 3307394. 
  3. ^ "Renal Pathology". Retrieved 2008-11-25. 
  4. ^ "Minimal_change_disease of the Kidney". Retrieved 2008-11-25. 
  5. ^ Mathieson P (2003). "Immune dysregulation in minimal change nephropathy". Nephrol Dial Transplant 18 Suppl 6: vi26–9. PMID 12953038. 
  6. ^ Ozaltin F, Ibsirlioglu T, Taskiran EZ, Baydar DE, Kaymaz F, Buyukcelik M, Kilic BD, Balat A, Iatropoulos P, Asan E, Akarsu NA, Schaefer F, Yilmaz E, Bakkaloglu A; the PodoNet Consortium (2011) Disruption of PTPRO Causes Childhood-Onset Nephrotic Syndrome. Am J Hum Genet
  7. ^ a b

External links

Wikimedia Foundation. 2010.

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