Histocompatibility is the property of having the same, or mostly the same,
alleles of a set of genes called the major histocompatibility complex. These genes are expressed in most tissues as antigens, to which the immune systemmakes antibodies. The immune system at first makes antibodies to all sorts of antigens, including those it has never been exposed to, but stops making them to antigens present in the body. If the body is exposed to foreign antigens, as by getting a tissue graft, it attacks the foreign material unless it is histocompatible.
A similar system exists in many
plants; its purpose is not to reject grafts, but to prevent inbreeding. Pollen from a plant sharing a histocompatibility gene with the female either fails to grow or dies soon after germinating.
Major histocompatibility complex
Clonal selection theory
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histocompatibility — histocompatibility. См. гистосовместимость. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) … Молекулярная биология и генетика. Толковый словарь.
histocompatibility — [his΄tōkem pat΄ə bil′ə tē] n. a condition of compatibility between the tissues of a graft or transplant and the tissues of the body receiving it … English World dictionary
histocompatibility — A state of immunologic similarity (or identity) that permits successful homograft transplantation. * * * his·to·com·pat·i·bil·i·ty his (.)tō kəm .pat ə bil ət ē n, pl ties often attrib a state of mutual tolerance between tissues that allows them… … Medical dictionary
histocompatibility — noun Date: 1948 a state of mutual tolerance that allows some tissues to be grafted effectively to others compare major histocompatibility complex … New Collegiate Dictionary
histocompatibility — If tissues of two organisms are histocompatible, then grafts between the organisms will not be rejected. If, however, major histocompatibility antigens are different then an immune response will be mounted against the foreign tissue … Dictionary of molecular biology
histocompatibility — histocompatible, adj. /his toh keuhm pat euh bil i tee/, n. Immunol. the condition of having antigenic similarities such that cells or tissues transplanted from one (the donor) to another (the recipient) are not rejected. Cf. major… … Universalium
histocompatibility — n. the form of compatibility that depends upon tissue components, mainly specific glycoprotein antigens in cell membranes. A high degree of histocompatibility is necessary for a tissue graft or organ transplant to be successful. Derivatives:… … The new mediacal dictionary
histocompatibility — noun condition in which the cells of one tissue can survive in the presence of cells of another tissue a successful graft or transplant requires a high degree of histocompatibility • Hypernyms: ↑organic phenomenon … Useful english dictionary
histocompatibility — noun the toleration of grafts between genetically similar individuals … Wiktionary
histocompatibility — noun Medicine compatibility between the tissues of different individuals … English new terms dictionary