- myeloma cell
Neoplastic plasma cell. The proliferating plasma cells often replace all the others within the marrow, leading to immune deficiency, and frequently there is destruction of the bone cortex. Because they are monoclonal in origin they secrete a monoclonal immunoglobulin. Bence-Jones proteins are monoclonal immunoglobulin light chains overproduced by myeloma cells and excreted in the urine. Myeloma cell lines are used for producing hybridomas in raising monoclonal antibodies.
Dictionary of molecular biology. 2004.
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