Naturally occurring inhibitor (68 residue peptide) of platelet aggregation found in the venom of Malayan pit viper Agkistrodon rhodostoma. Kistrin has an RGD site that competes for the platelet IIb/IIIa integrin and is therefore one of the disintegrins.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • Disintegrin — Strukturmodell eines Heterodimers von Echistatin Disintegrine sind Polypeptide, die erstmals aus dem Gift verschiedener Vipern (Viperidae) isoliert wurden. Die Sequenz findet sich aber auch als Disintegrin Domäne in einer Reihe humaner Enzyme,… …   Deutsch Wikipedia

  • Disintegrin — Structure of disintegrin heterodimer from Echis carinatus Identifiers Symbol Disintegrin …   Wikipedia

  • disintegrins — Peptides found in the venoms of various snakes of the viper family, that inhibit the function of some integrins of the b 1 and b 3 classes. They were first identified as inhibitors of platelet aggregation and were subsequently shown to bind with… …   Dictionary of molecular biology

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