frame-shift mutation

frame-shift mutation
Insertion or deletion of a number of bases not divisible by three in an open reading frame in a DNA sequence. Such mutations usually result in the generation, downstream, of nonsense, chain-termination codons.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • Frame-Shift-Mutation —   [ freɪm ʃɪft mjʊ teiʃn, englisch], Rastermutation, Molekulargentik: Genmutation, die zu einer Verschiebung des Triplettrasters in der Messenger Ribonukleinsäure und damit bei der Translation (Proteinbiosynthese) zum Einbau anderer Aminosäuren… …   Universal-Lexikon

  • frame|shift — «FRAYM SHIHFT», adjective. Genetics. having to do with or causing an insertion or deletion in a codon that results in an incorrect genetic message: »a frameshift mutation, a frameshift mutagen …   Useful english dictionary

  • Frame shift — Ein Frameshift oder Rasterschub beziehungsweise Leserasterverschiebung ist eine besondere Art der Mutation. Es handelt sich um eine Verschiebung des Leserasters von Genen auf der DNA. Die genetische Information auf der DNA ist in Form von… …   Deutsch Wikipedia

  • Mutation — Ausführung; Variante; Modifikation; Version; Anpassung; Derivat; Spielart (umgangssprachlich); Abart; Variation; Abwandlung; Veränderun …   Universal-Lexikon

  • Mutation — A permanent change, a structural alteration, in the DNA or RNA. In humans and many other organisms, mutations occur in DNA. However, in retroviruses like HIV, mutations occur in RNA which is the genetic material of retroviruses. In most cases,… …   Medical dictionary

  • mutation — Usage usually restricted to change in the DNA sequence of an organism, which may arise in any of a variety of different ways. See frame shift, nonsense and missense mutation …   Dictionary of molecular biology

  • Mutation — For other uses, see Mutation (disambiguation). Part of the Biology series on Evolution …   Wikipedia

  • Reading frame — One of the three possible ways to read a nucleotide sequence in DNA (depending upon whether reading starts with the first, second or third base in a triplet). * * * The grouping of nucleotides by threes into codons. See frame shift mutation.… …   Medical dictionary

  • deletion mutation — A mutation in which one or more (sequential) nucleotides is lost from the genome. If the number lost is not divisible by 3 and is in a coding region, the result is a frame shift mutation …   Dictionary of molecular biology

  • Reading frame — In biology, a reading frame is a contiguous and non overlapping set of three nucleotide codons in DNA or RNA. There are 3 possible reading frames in a mRNA strand and six in a double stranded DNA molecule due to the two strands from which… …   Wikipedia

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