Toxins from the American funnel web spider, Agalenopsis aperta. The m -toxins are 36-38 residue peptides that act on insect but not vertebrate voltage-sensitive sodium channels. The w -agatoxins are more diverse (5-9 kD) and act on various calcium channels, mostly in neuronal cells, blocking release of neurotransmitters. Affect vertebrate and invertebrate channels.
Dictionary of molecular biology. 2004.
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Agatoxin — Agatoxins are a class of chemically diverse polyamine and peptide toxins which are isolated from the venom of various spiders. Their mechanism of action includes blockade of glutamate gated ion channels, voltage gated sodium channels, or voltage… … Wikipedia
Voltage-dependent calcium channel — Voltage dependent calcium channels (VDCC) are a group of voltage gated ion channels found in excitable cells (e.g., muscle, glial cells, neurons, etc.) with a permeability to the ion Ca2+. These channels are slightly permeable to sodium… … Wikipedia
Agalenopsis aperta — American funnel web spider. See agatoxins … Dictionary of molecular biology
grammotoxin — (= w grammotoxin SIA) Toxin (peptide, 36 residues) from spider, Grammostola spatulata, that inhibits non L type voltage regulated calcium channels, thus resembling w conotoxins and w agatoxins. See VSCC … Dictionary of molecular biology