An actin depolymerizing factor (ADF) (13-15 kD) from protozoa ( Toxoplasma gondii, Acanthamoeba castellanii ) that will sever actin filaments and sequester G actin. Binds ADP-G-actin with higher affinity than ATP-actin and binding is very sensitive to the divalent cation present on the actin. Has high sequence homology with vertebrate cofilin and destrin, echinoderm depactin and some plant ADFs but lacks the nuclear localization sequence found in the vertebrate ADFs.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • Actin-binding protein — Actin binding proteins (also known as ABP) are proteins that bind to actin. This may mean ability to bind actin monomers, or polymers, or both.Many actin binding proteins, including α actinin, β spectrin, dystrophin, utrophin and fimbrin, do this …   Wikipedia

  • depactin — Actin depolymerizing protein (17.6 kD) originally isolated from echinoderm eggs. Similar to actophorin …   Dictionary of molecular biology

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