Protein originally isolated from smooth muscle (h-caldesmon; 120-150 kD on gels but 88.7 kD from sequence) also found in non-muscle cells (l-caldesmon; 70-80 kD on gels but 58.8 kD from sequence). Normally dimeric, binds to F-actin blocking the myosin binding site. Calcium-calmodulin binding to caldesmon causes its release from actin, though phosphorylation of caldesmon may also affect the link with actin. Caldesmon can block the effect of gelsolin on F-actin and will dissociate actin-gelsolin complexes and actin-profilin complexes.

Dictionary of molecular biology. 2004.

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