topoisomerase
noun Etymology: top- + isomerase Date: 1980 any of a class of enzymes that reduce supercoiling in DNA by breaking and rejoining one or both strands of the DNA molecule

New Collegiate Dictionary. 2001.

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  • Topoisomerase — Topoisomerases (type I: EC 5.99.1.2, type II: EC 5.99.1.3) are enzymes that regulate the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double helical structure. For example, during DNA… …   Wikipedia

  • Topoisomerase — Topoisomerasen Bezeichner Externe IDs CAS Nummer …   Deutsch Wikipedia

  • Topoisomérase — ADN topoïsomérase Les ADN topoïsomérases (de type I : ADN topo isomérases et de type II : ADN gyrases) sont des enzymes qui contrôlent la structure topologique de l’ADN en générant des coupures transitoires dans celui ci et en… …   Wikipédia en Français

  • topoisomerase — topoizomerazė statusas T sritis chemija apibrėžtis Fermentas, katalizuojantis ciklinės DNR struktūrinius pokyčius. atitikmenys: angl. topoisomerase rus. топоизомераза …   Chemijos terminų aiškinamasis žodynas

  • topoisomerase — noun Any of several enzymes that effect the topology of DNA, especially ones that relax supercoiling …   Wiktionary

  • topoisomerase — A type of enzyme converting (isomerizing) one topological version of DNA into another; acts by catalyzing the breakage and reformation of DNA phosphodiester linkages. [topo + isomerase] * * * topo·isom·er·ase .tō pō ī säm ə .rās, .rāz n any of a… …   Medical dictionary

  • Topoisomerase — To|po|i|so|me|ra|se [↑ topo u. ↑ Isomerase] Sammelbez. für Enzyme, die an der DNA Doppelhelix nur einen (T. I) oder beide (T. II oder ↑ Gyrase) Einzelstränge spalten u. wiedervereinigen, wobei Superhelices entstehen …   Universal-Lexikon

  • topoisomerase — topo·isom·er·ase …   English syllables

  • topoisomerase — ˌtōpōīˈsäməˌrās, rāz noun ( s) Etymology: top + isomerase : any of a class of enzymes that reduce supercoiling in DNA by breaking and rejoining one or both strands of the DNA molecule …   Useful english dictionary

  • Topoisomerase inhibitor — Topoisomerase inhibitors are agents designed to interfere with the action of topoisomerase enzymescite web |url=http://www.cancer.gov/Templates/db alpha.aspx?CdrID=46665 |title=Definition of topoisomerase inhibitor NCI Dictionary of Cancer Terms… …   Wikipedia

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