neurofibrillary tangle
noun Date: 1973 a pathological accumulation of paired helical filaments composed of abnormally formed tau protein that is found chiefly in the cytoplasm of neurons of the brain and especially the cerebral cortex and hippocampus and that occurs typically in Alzheimer's disease

New Collegiate Dictionary. 2001.

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  • neurofibrillary tangle — n a pathological accumulation of paired helical filaments composed of abnormally formed tau protein that is found chiefly in the cytoplasm of nerve cells of the brain and esp. the cerebral cortex and hippocampus and that occurs typically in… …   Medical dictionary

  • Neurofibrillary tangle — Microscopy image of a neurofibrillary tangle, conformed by hyperphosphorylated tau protein Neurofibrillary Tangles (NFTs) are aggregates of hyperphosphorylated tau protein that are most commonly known as a primary marker of Alzheimer s Disease.… …   Wikipedia

  • neurofibrillary tangle — A characteristic pathological feature of the brain of patients with Alzheimer&’s disease is the presence of tangles of coarse neurofibrils within large neurons of the cerebral cortex. Whether this causes neuronal degeneration or is a secondary… …   Dictionary of molecular biology

  • neurofibrillary tangle — noun : a pathological accumulation of paired helical filaments composed of abnormally formed tau protein that is found chiefly in the cytoplasm of nerve cells of the brain and especially the cerebral cortex and hippocampus and that occurs… …   Useful english dictionary

  • Tangle — may refer to: * Tangle (TV series), an Australian television series *Tangle theory, a branch of knot theory invented by John Horton Conway *Neurofibrillary tangles, which occur in Alzheimer s disease * Tangled Up , the fourth studio album by… …   Wikipedia

  • tangle — A small irregular knot. neurofibrillary t. intraneuronal accumulations of helical filaments that assume twisted contorted patterns; found in cells of the hippocampus and cerebral cortex in individuals with Alzheimer disease. * * * tan·gle taŋ gəl …   Medical dictionary

  • tangle — I. verb (tangled; tangling) Etymology: Middle English tanglen, tagilen, probably short for entanglen, from Anglo French entagler, entangler to prosecute (for), implicate Date: 14th century transitive verb 1. to involve so as to hamper, obstruct,… …   New Collegiate Dictionary

  • neurofibrillary tangles — intracellular knots or clumps of neurofibrils seen in the cerebral cortex in Alzheimer disease. Neurofibrillary tangle within neuronal cytoplasm (silver stain) …   Medical dictionary

  • tangle — [c]/ˈtæŋgəl / (say tangguhl) verb (tangled, tangling) –verb (t) 1. to bring together into a mass of confusedly interlaced or intertwisted threads, strands, or other like parts; snarl. 2. to involve in something that hampers, obstructs, or… …   Australian English dictionary

  • NFT — neurofibrillary tangle; no further treatment …   Medical dictionary

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