PRRX2

Paired related homeobox 2, also known as PRRX2, is a human gene.cite web | title = Entrez Gene: PRRX2 paired related homeobox 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51450| accessdate = ]

PBB_Summary
section_title =
summary_text = The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation.cite web | title = Entrez Gene: PRRX2 paired related homeobox 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51450| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Tokutomi Y, Araki N, Kataoka K, "et al." |title=Oxidation of Prx2 and phosphorylation of GRP58 by angiotensin II in human coronary smooth muscle cells identified by 2D-DIGE analysis. |journal=Biochem. Biophys. Res. Commun. |volume=364 |issue= 4 |pages= 822-30 |year= 2007 |pmid= 17964282 |doi= 10.1016/j.bbrc.2007.10.095
*cite journal | author=Wissmüller S, Kosian T, Wolf M, "et al." |title=The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. |journal=Nucleic Acids Res. |volume=34 |issue= 6 |pages= 1735-44 |year= 2006 |pmid= 16582099 |doi= 10.1093/nar/gkl105
*cite journal | author=Gervais C, Mauvieux L, Perrusson N, "et al." |title=A new translocation t(9;11)(q34;p15) fuses NUP98 to a novel homeobox partner gene, PRRX2, in a therapy-related acute myeloid leukemia. |journal=Leukemia |volume=19 |issue= 1 |pages= 145-8 |year= 2005 |pmid= 15496970 |doi= 10.1038/sj.leu.2403565
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Scott KK, Norris RA, Potter SS, "et al." |title=GeneChip microarrays facilitate identification of Protease Nexin-1 as a target gene of the Prx2 (S8) homeoprotein. |journal=DNA Cell Biol. |volume=22 |issue= 2 |pages= 95-105 |year= 2003 |pmid= 12713735 |doi= 10.1089/104454903321515904
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Jones FS, McKean DM, Meech R, "et al." |title=Regulation of vascular smooth muscle cell growth and adhesion by paired-related homeobox genes. |journal=Chest |volume=121 |issue= 3 Suppl |pages= 89S-90S |year= 2002 |pmid= 11893718 |doi=
*cite journal | author=Norris RA, Scott KK, Moore CS, "et al." |title=Human PRRX1 and PRRX2 genes: cloning, expression, genomic localization, and exclusion as disease genes for Nager syndrome. |journal=Mamm. Genome |volume=11 |issue= 11 |pages= 1000-5 |year= 2001 |pmid= 11063257 |doi=
*cite journal | author=Stelnicki EJ, Arbeit J, Cass DL, "et al." |title=Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds. |journal=J. Invest. Dermatol. |volume=111 |issue= 1 |pages= 57-63 |year= 1998 |pmid= 9665387 |doi= 10.1046/j.1523-1747.1998.00238.x

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