FBXO32

F-box protein 32, also known as FBXO32, is a human gene.cite web | title = Entrez Gene: FBXO32 F-box protein 32| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114907| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing of this gene results in two transcript variants encoding two isoforms of different sizes.cite web | title = Entrez Gene: FBXO32 F-box protein 32| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114907| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hanai J, Cao P, Tanksale P, "et al." |title=The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity. |journal=J. Clin. Invest. |volume=117 |issue= 12 |pages= 3940–51 |year= 2008 |pmid= 17992259 |doi= 10.1172/JCI32741
*cite journal | author=de Palma L, Marinelli M, Pavan M, Orazi A |title=Ubiquitin ligases MuRF1 and MAFbx in human skeletal muscle atrophy. |journal=Joint Bone Spine |volume=75 |issue= 1 |pages= 53–7 |year= 2008 |pmid= 17977773 |doi= 10.1016/j.jbspin.2007.04.019
*cite journal | author=Mascher H, Tannerstedt J, Brink-Elfegoun T, "et al." |title=Repeated resistance exercise training induces different changes in mRNA expression of MAFbx and MuRF-1 in human skeletal muscle. |journal=Am. J. Physiol. Endocrinol. Metab. |volume=294 |issue= 1 |pages= E43–51 |year= 2008 |pmid= 17971512 |doi= 10.1152/ajpendo.00504.2007
*cite journal | author=de Boer MD, Selby A, Atherton P, "et al." |title=The temporal responses of protein synthesis, gene expression and cell signalling in human quadriceps muscle and patellar tendon to disuse. |journal=J. Physiol. (Lond.) |volume=585 |issue= Pt 1 |pages= 241–51 |year= 2008 |pmid= 17901116 |doi= 10.1113/jphysiol.2007.142828
*cite journal | author=Petersen AM, Magkos F, Atherton P, "et al." |title=Smoking impairs muscle protein synthesis and increases the expression of myostatin and MAFbx in muscle. |journal=Am. J. Physiol. Endocrinol. Metab. |volume=293 |issue= 3 |pages= E843–8 |year= 2007 |pmid= 17609255 |doi= 10.1152/ajpendo.00301.2007
*cite journal | author=Kostek MC, Chen YW, Cuthbertson DJ, "et al." |title=Gene expression responses over 24 h to lengthening and shortening contractions in human muscle: major changes in CSRP3, MUSTN1, SIX1, and FBXO32. |journal=Physiol. Genomics |volume=31 |issue= 1 |pages= 42–52 |year= 2007 |pmid= 17519359 |doi= 10.1152/physiolgenomics.00151.2006
*cite journal | author=Doucet M, Russell AP, Léger B, "et al." |title=Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease. |journal=Am. J. Respir. Crit. Care Med. |volume=176 |issue= 3 |pages= 261–9 |year= 2007 |pmid= 17478621 |doi= 10.1164/rccm.200605-704OC
*cite journal | author=Ogawa T, Furochi H, Mameoka M, "et al." |title=Ubiquitin ligase gene expression in healthy volunteers with 20-day bedrest. |journal=Muscle Nerve |volume=34 |issue= 4 |pages= 463–9 |year= 2006 |pmid= 16868939 |doi= 10.1002/mus.20611
*cite journal | author=Léger B, Vergani L, Sorarù G, "et al." |title=Human skeletal muscle atrophy in amyotrophic lateral sclerosis reveals a reduction in Akt and an increase in atrogin-1. |journal=FASEB J. |volume=20 |issue= 3 |pages= 583–5 |year= 2006 |pmid= 16507768 |doi= 10.1096/fj.05-5249fje
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gomes MD, Lecker SH, Jagoe RT, "et al." |title=Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 25 |pages= 14440–5 |year= 2002 |pmid= 11717410 |doi= 10.1073/pnas.251541198
*cite journal | author=Bodine SC, Latres E, Baumhueter S, "et al." |title=Identification of ubiquitin ligases required for skeletal muscle atrophy. |journal=Science |volume=294 |issue= 5547 |pages= 1704–8 |year= 2001 |pmid= 11679633 |doi= 10.1126/science.1065874

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