Synaptosome

Synaptosome

A synaptosome is an isolated synapse of a neuron. "Synaptosomes" are obtained after homogenization and fractionation of nerve tissue. The fractionation step involves several centrifugations to separate various organelles from the synaptosomes. Synaptosomes are formed from the phospholipid layer of the cell membrane and synaptic proteins such as receptors.Synaptosomes are commonly used to study synaptic transmission because they contain the molecular machinery necessary for the uptake, storage, and release of neurotransmitters and because they are relatively easy to prepare in the laboratory.

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  • synaptosome — [si nap′tə sōm΄] n. 〚see SYNAPSIS & SOME3〛 a tiny sac of special cellular materials found at a synapse * * * syn·ap·to·some (sĭ năpʹtə sōm ) n. A saclike structure formed by nerve endings at a synapse that remains intact after homog …   Universalium

  • synaptosome — [si nap′tə sōm΄] n. [see SYNAPSIS & SOME3] a tiny sac of special cellular materials found at a synapse …   English World dictionary

  • synaptosome — noun Etymology: synaptic + o + 3 some Date: 1964 a nerve ending that is isolated from homogenized nerve tissue (as of the brain) • synaptosomal adjective …   New Collegiate Dictionary

  • synaptosome — A subcellular fraction prepared from tissues rich in chemical synapses, used in biochemical studies. Consists mainly of vesicles from presynaptic terminals …   Dictionary of molecular biology

  • synaptosome — noun A structure containing vesicles and mitochondria of a synapse that is obtained when brain tissue is homogenized …   Wiktionary

  • synaptosome — Membrane bound sac containing synaptic vesicles that breaks away from axon terminals when brain tissue is homogenized under controlled conditions; such particles can be separated from other subcellular particles by differential and density… …   Medical dictionary

  • synaptosome — syn·ap·to·some …   English syllables

  • synaptosome — …   Useful english dictionary

  • Cortical synaptosome — Cortical Synatosome is family of drugs, derived from isoquinoline, used to treat depression by preventing reuptake of dopamine by synaptosomes. The maleate was withdrawn from use in 1986 due to side effects including hemolytic anemia and renal… …   Wikipedia

  • SNAP-25 — synaptosome associated protein of 25 kilodaltons …   Medical dictionary

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