LOXL4

Lysyl oxidase-like 4, also known as LOXL4, is a human gene.cite web | title = Entrez Gene: LOXL4 lysyl oxidase-like 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84171| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.cite web | title = Entrez Gene: LOXL4 lysyl oxidase-like 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84171| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Molnar J, Fong KS, He QP, "et al." |title=Structural and functional diversity of lysyl oxidase and the LOX-like proteins. |journal=Biochim. Biophys. Acta |volume=1647 |issue= 1-2 |pages= 220–4 |year= 2003 |pmid= 12686136 |doi=
*cite journal | author=Ito H, Akiyama H, Iguchi H, "et al." |title=Molecular cloning and biological activity of a novel lysyl oxidase-related gene expressed in cartilage. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 24023–9 |year= 2001 |pmid= 11292829 |doi= 10.1074/jbc.M100861200
*cite journal | author=Asuncion L, Fogelgren B, Fong KS, "et al." |title=A novel human lysyl oxidase-like gene (LOXL4) on chromosome 10q24 has an altered scavenger receptor cysteine rich domain. |journal=Matrix Biol. |volume=20 |issue= 7 |pages= 487–91 |year= 2002 |pmid= 11691588 |doi=
*cite journal | author=Mäki JM, Tikkanen H, Kivirikko KI |title=Cloning and characterization of a fifth human lysyl oxidase isoenzyme: the third member of the lysyl oxidase-related subfamily with four scavenger receptor cysteine-rich domains. |journal=Matrix Biol. |volume=20 |issue= 7 |pages= 493–6 |year= 2002 |pmid= 11691589 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Holtmeier C, Görögh T, Beier U, "et al." |title=Overexpression of a novel lysyl oxidase-like gene in human head and neck squamous cell carcinomas. |journal=Anticancer Res. |volume=23 |issue= 3B |pages= 2585–91 |year= 2003 |pmid= 12894545 |doi=
*cite journal | author=Kim MS, Kim SS, Jung ST, "et al." |title=Expression and purification of enzymatically active forms of the human lysyl oxidase-like protein 4. |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52071–4 |year= 2004 |pmid= 14551188 |doi= 10.1074/jbc.M308856200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
*cite journal | author=Shieh TM, Lin SC, Liu CJ, "et al." |title=Association of expression aberrances and genetic polymorphisms of lysyl oxidase with areca-associated oral tumorigenesis. |journal=Clin. Cancer Res. |volume=13 |issue= 15 Pt 1 |pages= 4378–85 |year= 2007 |pmid= 17671119 |doi= 10.1158/1078-0432.CCR-06-2685

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