TREML1

Triggering receptor expressed on myeloid cells-like 1, also known as TREML1, is a human gene.cite web | title = Entrez Gene: TREML1 triggering receptor expressed on myeloid cells-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=340205| accessdate = ]

PBB_Summary
section_title =
summary_text = TREML1 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties. TREML1 enhances calcium signaling in an SHP2 (PTPN11; MIM 176876)-dependent manner (Allcock et al., 2003; Barrow et al., 2004). [supplied by OMIM] cite web | title = Entrez Gene: TREML1 triggering receptor expressed on myeloid cells-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=340205| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Washington AV, Quigley L, McVicar DW |title=Initial characterization of TREM-like transcript (TLT)-1: a putative inhibitory receptor within the TREM cluster. |journal=Blood |volume=100 |issue= 10 |pages= 3822–4 |year= 2003 |pmid= 12393607 |doi= 10.1182/blood-2002-02-0523
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Allcock RJ, Barrow AD, Forbes S, "et al." |title=The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. |journal=Eur. J. Immunol. |volume=33 |issue= 2 |pages= 567–77 |year= 2003 |pmid= 12645956 |doi= 10.1002/immu.200310033
*cite journal | author=Gevaert K, Goethals M, Martens L, "et al." |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Washington AV, Schubert RL, Quigley L, "et al." |title=A TREM family member, TLT-1, is found exclusively in the alpha-granules of megakaryocytes and platelets. |journal=Blood |volume=104 |issue= 4 |pages= 1042–7 |year= 2005 |pmid= 15100151 |doi= 10.1182/blood-2004-01-0315
*cite journal | author=Barrow AD, Astoul E, Floto A, "et al." |title=Cutting edge: TREM-like transcript-1, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than inhibits, calcium signaling via SHP-2. |journal=J. Immunol. |volume=172 |issue= 10 |pages= 5838–42 |year= 2004 |pmid= 15128762 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Gattis JL, Washington AV, Chisholm MM, "et al." |title=The structure of the extracellular domain of triggering receptor expressed on myeloid cells like transcript-1 and evidence for a naturally occurring soluble fragment. |journal=J. Biol. Chem. |volume=281 |issue= 19 |pages= 13396–403 |year= 2006 |pmid= 16505478 |doi= 10.1074/jbc.M600489200
*cite journal | author=Giomarelli B, Washington VA, Chisholm MM, "et al." |title=Inhibition of thrombin-induced platelet aggregation using human single-chain Fv antibodies specific for TREM-like transcript-1. |journal=Thromb. Haemost. |volume=97 |issue= 6 |pages= 955–63 |year= 2007 |pmid= 17549298 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes