- COQ2
Coenzyme Q2 homolog, prenyltransferase (yeast), also known as COQ2, is a human
gene .cite web | title = Entrez Gene: COQ2 coenzyme Q2 homolog, prenyltransferase (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27235| accessdate = ]PBB_Summary
section_title =
summary_text = CoQ (ubiquinone) serves as a redox carrier in the mitochondrial respiratory chain and is a lipid-soluble antioxidant. COQ2, or parahydroxybenzoate-polyprenyltransferase (EC 2.5.1.39), catalyzes one of the final reactions in the biosynthesis of CoQ, the prenylation of parahydroxybenzoate with an all-trans polyprenyl group (Forsgren et al., 2004). [supplied by OMIM] cite web | title = Entrez Gene: COQ2 coenzyme Q2 homolog, prenyltransferase (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27235| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, "et al." |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Forsgren M, Attersand A, Lake S, "et al." |title=Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ. |journal=Biochem. J. |volume=382 |issue= Pt 2 |pages= 519–26 |year= 2005 |pmid= 15153069 |doi= 10.1042/BJ20040261
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Esaka Y, Nagahara Y, Hasome Y, "et al." |title=Coenzyme Q2 induced p53-dependent apoptosis. |journal=Biochim. Biophys. Acta |volume=1724 |issue= 1-2 |pages= 49–58 |year= 2005 |pmid= 15905035 |doi= 10.1016/j.bbagen.2005.04.013
*cite journal | author=Quinzii C, Naini A, Salviati L, "et al." |title=A mutation in para-hydroxybenzoate-polyprenyl transferase (COQ2) causes primary coenzyme Q10 deficiency. |journal=Am. J. Hum. Genet. |volume=78 |issue= 2 |pages= 345–9 |year= 2007 |pmid= 16400613 |doi= 10.1086/500092
*cite journal | author=Burón MI, Hermán MD, Alcaín FJ, Villalba JM |title=Stimulation of polyprenyl 4-hydroxybenzoate transferase activity by sodium cholate and 3- [(cholamidopropyl)dimethylammonio] -1-propanesulfonate. |journal=Anal. Biochem. |volume=353 |issue= 1 |pages= 15–21 |year= 2006 |pmid= 16643834 |doi= 10.1016/j.ab.2006.03.029
*cite journal | author=González-Aragón D, Burón MI, López-Lluch G, "et al." |title=Coenzyme Q and the regulation of intracellular steady-state levels of superoxide in HL-60 cells. |journal=Biofactors |volume=25 |issue= 1-4 |pages= 31–41 |year= 2006 |pmid= 16873928 |doi=
*cite journal | author=Mollet J, Giurgea I, Schlemmer D, "et al." |title=Prenyldiphosphate synthase, subunit 1 (PDSS1) and OH-benzoate polyprenyltransferase (COQ2) mutations in ubiquinone deficiency and oxidative phosphorylation disorders. |journal=J. Clin. Invest. |volume=117 |issue= 3 |pages= 765–72 |year= 2007 |pmid= 17332895 |doi= 10.1172/JCI29089
*cite journal | author=López-Martín JM, Salviati L, Trevisson E, "et al." |title=Missense mutation of the COQ2 gene causes defects of bioenergetics and de novo pyrimidine synthesis. |journal=Hum. Mol. Genet. |volume=16 |issue= 9 |pages= 1091–7 |year= 2007 |pmid= 17374725 |doi= 10.1093/hmg/ddm058
*cite journal | author=Oh J, Ban MR, Miskie BA, "et al." |title=Genetic determinants of statin intolerance. |journal=Lipids in health and disease |volume=6 |issue= |pages= 7 |year= 2007 |pmid= 17376224 |doi= 10.1186/1476-511X-6-7
*cite journal | author=Diomedi-Camassei F, Di Giandomenico S, Santorelli FM, "et al." |title=COQ2 nephropathy: a newly described inherited mitochondriopathy with primary renal involvement. |journal=J. Am. Soc. Nephrol. |volume=18 |issue= 10 |pages= 2773–80 |year= |pmid= 17855635 |doi= 10.1681/ASN.2006080833PBB_Controls
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