PDZD2

PDZD2
PDZ domain containing 2
Identifiers
Symbols PDZD2; AIPC; KIAA0300; PAPIN; PDZK3; PIN1
External IDs OMIM610697 MGI1922394 HomoloGene23393 GeneCards: PDZD2 Gene
RNA expression pattern
PBB GE PDZD2 209493 at tn.png
PBB GE PDZD2 gnf1h07921 at tn.png
PBB GE PDZD2 gnf1h07922 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 23037 68070
Ensembl ENSG00000133401 ENSMUSG00000022197
UniProt O15018 n/a
RefSeq (mRNA) NM_178140 NM_001081064.1
RefSeq (protein) NP_835260 NP_001074533.1
Location (UCSC) Chr 5:
31.64 – 32.11 Mb
Chr 15:
12.29 – 12.67 Mb
PubMed search [1] [2]

PDZ domain-containing protein 2 is a protein that in humans is encoded by the PDZD2 gene.[1][2]

Proteins containing PDZ domains have been shown frequently to bind the C-termini of transmembrane receptors or ion channels. They have also been shown to bind to other PDZ domain proteins and could possibly be involved in intracellular signalling. The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis.[2]

Interactions

PDZD2 has been shown to interact with PKP4.[3][4]

References

  1. ^ Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Sep 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841. 
  2. ^ a b "Entrez Gene: PDZD2 PDZ domain containing 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23037. 
  3. ^ Deguchi, M; Iizuka T, Hata Y, Nishimura W, Hirao K, Yao I, Kawabe H, Takai Y (Sep. 2000). "PAPIN. A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin and p0071". J. Biol. Chem. (UNITED STATES) 275 (38): 29875–80. doi:10.1074/jbc.M005384200. ISSN 0021-9258. PMID 10896674. 
  4. ^ Ohno, Hideki; Hirabayashi Susumu, Iizuka Toshihiko, Ohnishi Hirohide, Fujita Toshiro, Hata Yutaka (Oct. 2002). "Localization of p0071-interacting proteins, plakophilin-related armadillo-repeat protein-interacting protein (PAPIN) and ERBIN, in epithelial cells". Oncogene (England) 21 (46): 7042–9. doi:10.1038/sj.onc.1205852. ISSN 0950-9232. PMID 12370826. 

Further reading


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  • PDZ domain — Molecular structure of the PDZ domain included in the human GOPC (Golgi associated PDZ and coiled coil motif containing protein) protein Identifiers Symbol PDZ …   Wikipedia

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