SLC12A6

Solute carrier family 12 (potassium/chloride transporters), member 6, also known as SLC12A6, is a human gene.cite web | title = Entrez Gene: SLC12A6 solute carrier family 12 (potassium/chloride transporters), member 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9990| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy.cite web | title = Entrez Gene: SLC12A6 solute carrier family 12 (potassium/chloride transporters), member 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9990| accessdate = ]

ee also

* Solute carrier family

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hiki K, D'Andrea RJ, Furze J, "et al." |title=Cloning, characterization, and chromosomal location of a novel human K+-Cl- cotransporter. |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 10661–7 |year= 1999 |pmid= 10187864 |doi=
*cite journal | author=Mount DB, Mercado A, Song L, "et al." |title=Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family. |journal=J. Biol. Chem. |volume=274 |issue= 23 |pages= 16355–62 |year= 1999 |pmid= 10347194 |doi=
*cite journal | author=Race JE, Makhlouf FN, Logue PJ, "et al." |title=Molecular cloning and functional characterization of KCC3, a new K-Cl cotransporter. |journal=Am. J. Physiol. |volume=277 |issue= 6 Pt 1 |pages= C1210–9 |year= 2000 |pmid= 10600773 |doi=
*cite journal | author=Casula S, Shmukler BE, Wilhelm S, "et al." |title=A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity. |journal=J. Biol. Chem. |volume=276 |issue= 45 |pages= 41870–8 |year= 2001 |pmid= 11551954 |doi= 10.1074/jbc.M107155200
*cite journal | author=Howard HC, Mount DB, Rochefort D, "et al." |title=The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum. |journal=Nat. Genet. |volume=32 |issue= 3 |pages= 384–92 |year= 2002 |pmid= 12368912 |doi= 10.1038/ng1002
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Bräuer M, Frei E, Claes L, "et al." |title=Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl- channels in human osteoblasts. |journal=Am. J. Physiol., Cell Physiol. |volume=285 |issue= 1 |pages= C22–30 |year= 2003 |pmid= 12637262 |doi= 10.1152/ajpcell.00289.2002
*cite journal | author=Bergeron MJ, Gagnon E, Wallendorff B, "et al." |title=Ammonium transport and pH regulation by K(+)-Cl(-) cotransporters. |journal=Am. J. Physiol. Renal Physiol. |volume=285 |issue= 1 |pages= F68–78 |year= 2003 |pmid= 12657561 |doi= 10.1152/ajprenal.00032.2003
*cite journal | author=Shen MR, Lin AC, Hsu YM, "et al." |title=Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells. |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 40017–25 |year= 2004 |pmid= 15262997 |doi= 10.1074/jbc.M406706200
*cite journal | author=Mercado A, Vázquez N, Song L, "et al." |title=NH2-terminal heterogeneity in the KCC3 K+-Cl- cotransporter. |journal=Am. J. Physiol. Renal Physiol. |volume=289 |issue= 6 |pages= F1246–61 |year= 2005 |pmid= 16048901 |doi= 10.1152/ajprenal.00464.2004
*cite journal | author=Uyanik G, Elcioglu N, Penzien J, "et al." |title=Novel truncating and missense mutations of the KCC3 gene associated with Andermann syndrome. |journal=Neurology |volume=66 |issue= 7 |pages= 1044–8 |year= 2006 |pmid= 16606917 |doi= 10.1212/01.wnl.0000204181.31175.8b
*cite journal | author=Hsu YM, Chou CY, Chen HH, "et al." |title=IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness. |journal=J. Cell. Physiol. |volume=210 |issue= 3 |pages= 626–36 |year= 2007 |pmid= 17133354 |doi= 10.1002/jcp.20859
*cite journal | author=Salin-Cantegrel A, Rivière JB, Dupré N, "et al." |title=Distal truncation of KCC3 in non-French Canadian HMSN/ACC families. |journal=Neurology |volume=69 |issue= 13 |pages= 1350–5 |year= 2007 |pmid= 17893295 |doi= 10.1212/01.wnl.0000291779.35643.15
*cite journal | author=Hsu YM, Chen YF, Chou CY, "et al." |title=KCl cotransporter-3 down-regulates E-cadherin/beta-catenin complex to promote epithelial-mesenchymal transition. |journal=Cancer Res. |volume=67 |issue= 22 |pages= 11064–73 |year= 2007 |pmid= 18006853 |doi= 10.1158/0008-5472.CAN-07-2443

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