SLC25A14

Solute carrier family 25 (mitochondrial carrier, brain), member 14, also known as SLC25A14, is a human gene.cite web | title = Entrez Gene: SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9016| accessdate = ]

PBB_Summary
section_title =
summary_text = Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is widely expressed in many tissues with the greatest abundance in brain and testis. The gene product has an N-terminal hydrophobic domain that is not present in other UCPs. Two splice variants have been found for this gene.cite web | title = Entrez Gene: SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9016| accessdate = ]

ee also

* Solute carrier family
* Uncoupling protein

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ricquier D, Bouillaud F |title=The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. |journal=Biochem. J. |volume=345 Pt 2 |issue= |pages= 161–79 |year= 2000 |pmid= 10620491 |doi=
*cite journal | author=Sanchis D, Fleury C, Chomiki N, "et al." |title=BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast. |journal=J. Biol. Chem. |volume=273 |issue= 51 |pages= 34611–5 |year= 1999 |pmid= 9852133 |doi=
*cite journal | author=Jezek P, Urbánková E |title=Specific sequence of motifs of mitochondrial uncoupling proteins. |journal=IUBMB Life |volume=49 |issue= 1 |pages= 63–70 |year= 2000 |pmid= 10772343 |doi=
*cite journal | author=Yu XX, Mao W, Zhong A, "et al." |title=Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation. |journal=FASEB J. |volume=14 |issue= 11 |pages= 1611–8 |year= 2000 |pmid= 10928996 |doi=
*cite journal | author=Kim-Han JS, Reichert SA, Quick KL, Dugan LL |title=BMCP1: a mitochondrial uncoupling protein in neurons which regulates mitochondrial function and oxidant production. |journal=J. Neurochem. |volume=79 |issue= 3 |pages= 658–68 |year= 2001 |pmid= 11701769 |doi=
*cite journal | author=Yang X, Pratley RE, Tokraks S, "et al." |title=UCP5/BMCP1 transcript isoforms in human skeletal muscle: relationship of the short-insert isoform with lipid oxidation and resting metabolic rates. |journal=Mol. Genet. Metab. |volume=75 |issue= 4 |pages= 369–73 |year= 2002 |pmid= 12051969 |doi= 10.1016/S1096-7192(02)00008-2
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ross MT, Grafham DV, Coffey AJ, "et al." |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440
*cite journal | author=Ho PW, Chu AC, Kwok KH, "et al." |title=Knockdown of uncoupling protein-5 in neuronal SH-SY5Y cells: Effects on MPP+-induced mitochondrial membrane depolarization, ATP deficiency, and oxidative cytotoxicity. |journal=J. Neurosci. Res. |volume=84 |issue= 6 |pages= 1358–66 |year= 2007 |pmid= 16941493 |doi= 10.1002/jnr.21034
*cite journal | author=Yasuno K, Ando S, Misumi S, "et al." |title=Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia. |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=144 |issue= 2 |pages= 250–3 |year= 2007 |pmid= 17066476 |doi= 10.1002/ajmg.b.30443

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