SLC22A18

Solute carrier family 22 (organic cation transporter), member 18, also known as SLC22A18, is a human gene.cite web | title = Entrez Gene: SLC22A18 solute carrier family 22 (organic cation transporter), member 18| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5002| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region as well as the transport of chloroquine- and quinidine-related compounds in the kidney. Two alternative transcripts encoding the same isoform have been described.cite web | title = Entrez Gene: SLC22A18 solute carrier family 22 (organic cation transporter), member 18| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5002| accessdate = ]

ee also

* Solute carrier family

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Akiyama S |title= [Mechanisms of drug resistance and reversal of the resistance] |journal=Hum. Cell |volume=14 |issue= 4 |pages= 257–60 |year= 2002 |pmid= 11925925 |doi=
*cite journal | author=Dao D, Frank D, Qian N, "et al." |title=IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes. |journal=Hum. Mol. Genet. |volume=7 |issue= 4 |pages= 597–608 |year= 1998 |pmid= 9499412 |doi=
*cite journal | author=Schwienbacher C, Sabbioni S, Campi M, "et al." |title=Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 7 |pages= 3873–8 |year= 1998 |pmid= 9520460 |doi=
*cite journal | author=Cooper PR, Smilinich NJ, Day CD, "et al." |title=Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain. |journal=Genomics |volume=49 |issue= 1 |pages= 38–51 |year= 1998 |pmid= 9570947 |doi= 10.1006/geno.1998.5221
*cite journal | author=Reece M, Prawitt D, Landers J, "et al." |title=Functional characterization of ORCTL2--an organic cation transporter expressed in the renal proximal tubules. |journal=FEBS Lett. |volume=433 |issue= 3 |pages= 245–50 |year= 1998 |pmid= 9744804 |doi=
*cite journal | author=Lee MP, Reeves C, Schmitt A, "et al." |title=Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5. |journal=Cancer Res. |volume=58 |issue= 18 |pages= 4155–9 |year= 1998 |pmid= 9751628 |doi=
*cite journal | author=Morisaki H, Hatada I, Morisaki T, Mukai T |title=A novel gene, ITM, located between p57KIP2 and IPL, is imprinted in mice. |journal=DNA Res. |volume=5 |issue= 4 |pages= 235–40 |year= 1999 |pmid= 9802569 |doi=
*cite journal | author=Onyango P, Miller W, Lehoczky J, "et al." |title=Sequence and comparative analysis of the mouse 1-megabase region orthologous to the human 11p15 imprinted domain. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1697–710 |year= 2001 |pmid= 11076855 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Yamada HY, Gorbsky GJ |title=Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105. |journal=Oncogene |volume=25 |issue= 9 |pages= 1330–9 |year= 2006 |pmid= 16314844 |doi= 10.1038/sj.onc.1209167
*cite journal | author=Gallagher E, Mc Goldrick A, Chung WY, "et al." |title=Gain of imprinting of SLC22A18 sense and antisense transcripts in human breast cancer. |journal=Genomics |volume=88 |issue= 1 |pages= 12–7 |year= 2006 |pmid= 16624517 |doi= 10.1016/j.ygeno.2006.02.004

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