TAC1

Tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma), also known as TAC1, is a human gene.cite web | title = Entrez Gene: TAC1 tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6863| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Alternative splicing of exons 4 and/or 6 produces four known products of undetermined significance.cite web | title = Entrez Gene: TAC1 tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6863| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kowall NW, Quigley BJ, Krause JE, "et al." |title=Substance P and substance P receptor histochemistry in human neurodegenerative diseases. |journal=Regul. Pept. |volume=46 |issue= 1-2 |pages= 174–85 |year= 1993 |pmid= 7692486 |doi=
*cite journal | author=Advenier C, Lagente V, Boichot E |title=The role of tachykinin receptor antagonists in the prevention of bronchial hyperresponsiveness, airway inflammation and cough. |journal=Eur. Respir. J. |volume=10 |issue= 8 |pages= 1892–906 |year= 1997 |pmid= 9272936 |doi=
*cite journal | author=Rameshwar P, Oh HS, Yook C, "et al." |title=Substance p-fibronectin-cytokine interactions in myeloproliferative disorders with bone marrow fibrosis. |journal=Acta Haematol. |volume=109 |issue= 1 |pages= 1–10 |year= 2003 |pmid= 12486316 |doi=
*cite journal | author=Saito R, Takano Y, Kamiya HO |title=Roles of substance P and NK(1) receptor in the brainstem in the development of emesis. |journal=J. Pharmacol. Sci. |volume=91 |issue= 2 |pages= 87–94 |year= 2003 |pmid= 12686752 |doi=
*cite journal | author=Di Angelantonio S, Giniatullin R, Costa V, "et al." |title=Modulation of neuronal nicotinic receptor function by the neuropeptides CGRP and substance P on autonomic nerve cells. |journal=Br. J. Pharmacol. |volume=139 |issue= 6 |pages= 1061–73 |year= 2004 |pmid= 12871824 |doi= 10.1038/sj.bjp.0705337
*cite journal | author=Bannon MJ, Poosch MS, Haverstick DM, "et al." |title=Preprotachykinin gene expression in the human basal ganglia: characterization of mRNAs and pre-mRNAs produced by alternate RNA splicing. |journal=Brain Res. Mol. Brain Res. |volume=12 |issue= 1-3 |pages= 225–31 |year= 1992 |pmid= 1312203 |doi=
*cite journal | author=Chiwakata C, Brackmann B, Hunt N, "et al." |title=Tachykinin (substance-P) gene expression in Leydig cells of the human and mouse testis. |journal=Endocrinology |volume=128 |issue= 5 |pages= 2441–8 |year= 1991 |pmid= 1708336 |doi=
*cite journal | author=McGregor GP, Conlon JM |title=Characterization of the C-terminal flanking peptide of human beta-preprotachykinin. |journal=Peptides |volume=11 |issue= 5 |pages= 907–10 |year= 1991 |pmid= 2284201 |doi=
*cite journal | author=Theodorsson-Norheim E, Jörnvall H, Andersson M, "et al." |title=Isolation and characterization of neurokinin A, neurokinin A(3-10) and neurokinin A(4-10) from a neutral water extract of a metastatic ileal carcinoid tumour. |journal=Eur. J. Biochem. |volume=166 |issue= 3 |pages= 693–7 |year= 1987 |pmid= 3038549 |doi=
*cite journal | author=Harmar AJ, Armstrong A, Pascall JC, "et al." |title=cDNA sequence of human beta-preprotachykinin, the common precursor to substance P and neurokinin A. |journal=FEBS Lett. |volume=208 |issue= 1 |pages= 67–72 |year= 1986 |pmid= 3770210 |doi=
*cite journal | author=Bhogal N, Donnelly D, Findlay JB |title=The ligand binding site of the neurokinin 2 receptor. Site-directed mutagenesis and identification of neurokinin A binding residues in the human neurokinin 2 receptor. |journal=J. Biol. Chem. |volume=269 |issue= 44 |pages= 27269–74 |year= 1994 |pmid= 7961636 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Tian Y, Wu LH, Oxender DL, Chung FZ |title=The unpredicted high affinities of a large number of naturally occurring tachykinins for chimeric NK1/NK3 receptors suggest a role for an inhibitory domain in determining receptor specificity. |journal=J. Biol. Chem. |volume=271 |issue= 34 |pages= 20250–7 |year= 1996 |pmid= 8702757 |doi=
*cite journal | author=Tanabe T, Otani H, Zeng XT, "et al." |title=Inhibitory effects of calcitonin gene-related peptide on substance-P-induced superoxide production in human neutrophils. |journal=Eur. J. Pharmacol. |volume=314 |issue= 1-2 |pages= 175–83 |year= 1997 |pmid= 8957234 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Zimmer A, Zimmer AM, Baffi J, "et al." |title=Hypoalgesia in mice with a targeted deletion of the tachykinin 1 gene. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 5 |pages= 2630–5 |year= 1998 |pmid= 9482938 |doi=
*cite journal | author=Ho WZ, Lai JP, Zhu XH, "et al." |title=Human monocytes and macrophages express substance P and neurokinin-1 receptor. |journal=J. Immunol. |volume=159 |issue= 11 |pages= 5654–60 |year= 1998 |pmid= 9548509 |doi=
*cite journal | author=Lai JP, Douglas SD, Ho WZ |title=Human lymphocytes express substance P and its receptor. |journal=J. Neuroimmunol. |volume=86 |issue= 1 |pages= 80–6 |year= 1998 |pmid= 9655475 |doi=

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