2'-O-methylation

2'-O-methylation

[
adenosine.] 2'-"O"-methylation is a common nucleoside modification of RNA, where a methyl group is added to the 2' hydroxyl group of the ribose moiety of a nucleoside. 2'-"O"-methylated nucleosides are found in the functionally essential regions of the ribosome and spliceosome. [cite journal |author=Kiss T |title=Small nucleolar RNA-guided post-transcriptional modification of cellular RNAs |journal=EMBO J. |volume=20 |issue=14 |pages=3617–22 |year=2001 |url=http://www.nature.com/emboj/journal/v20/n14/full/7593858a.html |doi=10.1093/emboj/20.14.3617] Also, 2'-"O"-methylation of adenosine in an RNA prevents adenosine deaminase from editing it to an inosine. [cite journal |author=Beal PA, Maydanovych O, Pokharel S | title=The chemistry and biology of RNA editing by adenosine deaminases | journal=Nucleic Acids Symposium Series | date=2007 | doi=10.1093/nass/nrm042 | pages=83–84 | volume=51 | issue=1]

ee also

*Small nucleolar RNA

References


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